Effect of vanadium complexes and insulin administered simultaneously for oxidative stress in STZ diabetic rats

• Autorzy: Krosniak M. , Gawlik M. , Grybos R.
• Języki publikacji: EN

Abstrakty

EN

The objective of the study was to assess the effects of both 5-vanadium organic complexes with bipyridine and phenanthroline (1-5) and small insulin injections on oxidative stress indices in streptozotocin (STZ)-induced diabetes in rats (Dil- Di5). In all groups of the animals, the glucose, uric acid, urea, α-tocopherol, and SOD activity were measured in the plasma, and the GSH level was measured in the liver. The glucose level was higher in all the diabetic (D) rats; however, no differences were observed in the vanadium-treated STZ rats. Of all the STZ-treated rats, the highest level of uric acid was observed in the diabetic control group (CD). Substantial differences in the uric acid level were observed between the diabetic control group and some of the vanadium- treated groups: Dil, Di4, and Di5. Significant differences for the urea level were observed between all the diabetic rats and healthy rats. For the α-tocopherol level, a difference was observed only between the Di and Di3 groups. A difference in SOD activity was observed between the Di and Di4 groups. The type of vanadium complex also had an influence on SOD activity, where differences were observed in the Di3 group in contrast to the Di4 and Di5 groups. In three groups of vanadium-treated STZ diabetic rats (Dil, Di2 and Di4) the glutathione level in the liver was higher than in the STZ-diabetic rats, as well as in the normal control rats. In conclusion, the type of administered complexes of vanadium and diabetes had different influences on the antioxidant defence.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2009
• Tom: 53
• Numer: 3
• Opis fizyczny: p.535-540,fig.,ref.

Twórcy

autor

Krosniak M.

• Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, 30-688 Krakow, Poland

autor

Gawlik M.

• Department of Toxicology, Medical College, Jagiellonian University, 30-688 Krakow, Poland

autor

Grybos R.

• Faculty of Chemistry, Jagiellonian University, 30-060 Krakow, Poland

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