Microbial biotransformation of two phosphonoacetic acid derivatives bearing two stereomeric centres

• Autorzy: Szyszkowiak J. , Majewska P.
• Języki publikacji: EN

Abstrakty

EN

Three strains of microorganisms: Bacillus subtilis, Serratia liquefaciens and Escherichia coli were tested as whole-cell biocatalysts for the kinetic resolution of isomers of two new phosphonoacetic acid derivatives. Used compounds possess two chiral centres – one at the carbon adjacent to both functional groups and the other at the phosphorus. Biocatalytic hydrolysis of 2-butyryloxy-2-(butoxyetoxyphosphinyl)acetic acid and 2-butyryloxy-2-(isobutoxyetoxyphosphinyl) acetic acid with whole cells of Bacillus subtilis produced corresponding hydroxyphosphonates with diastereoselectivity ranging from 50 to 60%.

Słowa kluczowe

EN

biotransformation; Serratia liquefaciens; Bacillus subtilis; Escherichia coli; lipolytic activity; phosphonoacetic acid; biocatalysis

• Wydawca: -
• Czasopismo: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
• Rocznik: 2013
• Tom: 94
• Numer: 4
• Opis fizyczny: p.425-431,fig.,ref.

Twórcy

autor

Szyszkowiak J.

• Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw, Poland

autor

Majewska P.

• Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw, Poland

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