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2009 | 69 | 3 |
Tytuł artykułu

Effect of extra high power pulses and hydrogen peroxide on functional activity of neurons

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
It was recently shown that the exposure of aqueous solutions to highpeak-power microwave pulses leads to the formation of hydrogen peroxide (H202). The aim of this study was to evaluate the effects of extra high power pulses (EHPP,9.3 GHz, 101.2 kW/kg) millimeter waves and H202 on action potentials, acetylcholine chemosensitivity and cell volume of giant neurons from the parietal ganglion of Helix Pomatia by means of standard voltage-clamp method. H202 containing and EHPP treated physiological solutions increased the interburst period of neuronal pacemaker activity. In K-free physiological solution (when Na+ /K+ pump is inactive) the interburst period was higher than in normal one. Application of H202 containing and EHPP treated physiological solutions changed the number of active receptors on neuromembrane surface which caused depression of its chemosensitivity and decreased as a consequence of cell volume (cell shrinking). These comparative studies allowed us to suggest that EHPP induced formation of H2O2 is one of the main messenger through which the non-thermal biological effect of EHPP on functional activity of neurons is realized.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.338
Twórcy
autor
  • Department of Neuroscience and Pain, UNESCO Chair-Life Sciences International Postgraduate Education Center, Yerevan, Armenia
autor
  • Department of Neurobiology and Behavior, SUNY at Stony Brook, Stony Brook, NY, USA
autor
  • Department of Neuroscience and Pain, UNESCO Chair-Life Sciences International Postgraduate Education Center, Yerevan, Armenia
  • Department of Neuroscience and Pain, UNESCO Chair-Life Sciences International Postgraduate Education Center, Yerevan, Armenia
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-ec6e7081-717e-40b5-8baf-c950f5837359
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