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2009 | 69 | 3 |
Tytuł artykułu

Maternal separation affects tyrosine hydroxylase and NCAM expression in dopaminergic structures of juvenile adolescent and adult rat brain

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Stressful experiences in early life can infl uence brain development and increase the risk for mental disorders. However the specifi c impact of early life stress on maturation of dopaminergic (DA) system is still unknown. We applied maternal separation (MS) paradigm in rats, on postnatal (P) days 1–14, to investigate its impact on expression of tyrosine hydroxylase (TH) and NCAM proteins in DA structures of juvenile (P15), adolescent (P35) and adult (P70) rat brain. On P15 MS decreased the number of TH+ neurons in the substantia nigra (SN) pars compacta of females as well as in the SN pars reticulata (SNr) and the ventral tegmental area (VTA) of both females and males. The effect persisted until P35 only in the VTA of MS females. Oppositely on P70, an increase in the number of TH+ neurons was observed in the VTA of females. Additionally on P35 a transient rise in TH+ cells was detected in the SNr of MS females. MS did not change the expression of TH in the striatum, nucleus accumbens and medial prefrontal cortex (mPFC). On P15 a decrease in the level of 140 kDa NCAM was observed in the SN and striatum of MS females and a decrease in 180 kDa NCAM in the VTA of MS males. On P35 MS diminished the expression of 180 kDa NCAM in the SN and mPFC of females. Finally, on P70 a decrease in 180 kDa NCAM was observed in the mPFC of MS males. The results of the present study strongly indicate that early life stress can affect maturation and plasticity of DA system at different life stages.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.360
Twórcy
autor
  • Laboratory of Pharmacology and Brain Biostructure, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
autor
  • Laboratory of Pharmacology and Brain Biostructure, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
autor
  • Laboratory of Pharmacology and Brain Biostructure, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
  • Laboratory of Pharmacology and Brain Biostructure, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
autor
  • Laboratory of Pharmacology and Brain Biostructure, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-eb94b585-e62e-44d6-85e4-0cd2078113f8
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