Influence of emotional arousal on the N150 of the Auditory Evoked Potential from the rat amygdala

• Autorzy: Knippenberg J.M.J. , Maes J. H. R. , Coenen A. M. L. , van Luijtelaar G. L. J. M.
• Języki publikacji: EN

Abstrakty

EN

This study tested whether a general increase in emotional arousal is a sufficient determinant for the evocation of the N150, a negative wave in amygdalar Auditory Evoked Potentials (AEPs). Rats received one of three conditioning protocols: either conditioned stimulus (CS) presentations alone (Control), CS-shock pairings (Paired), or unpaired presentations of the CS and shock (Unpaired). Amygdalar AEPs were recorded in response to the CS. It was hypothesized that if a state of emotional arousal is a sufficient condition for the manifestation of the N150, its amplitude should be enhanced in the Paired and Unpaired conditions relative to the Control condition, which was indeed found. In addition, it was found that the N150 had a larger amplitude in the Paired than in the Unpaired condition. This suggests that an additional N150 increase is established when animals learn the CS-US association. The results are discussed in relation to literature on amygdala function.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 1
• Opis fizyczny: p.109-118,fig.,ref.

Twórcy

autor

Knippenberg J.M.J.

• Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognition, Radboud University Nijmegen, Nijmegen, The Netherlands

autor

Maes J. H. R.

• Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognition, Radboud University Nijmegen, Nijmegen, The Netherlands

autor

Coenen A. M. L.

• Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognition, Radboud University Nijmegen, Nijmegen, The Netherlands

autor

van Luijtelaar G. L. J. M.

• Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognition, Radboud University Nijmegen, Nijmegen, The Netherlands

Bibliografia

• Antoniadis EA, McDonald RJ (1999) Discriminative fear conditioning to context expressed by multiple measures of fear in the rat. Behav Brain Res 101: 1-13.
• Antoniadis EA, McDonald RJ (2000) Amygdala, hippocam­pus and discriminative fear conditioning to context. Behav Brain Res 108: 1-19.
• Blair HT, Schafe GE, Bauer EP, Rodrigues SM, LeDoux JE (2001) Synaptic plasticity in the lateral amygdala: A cel­lular hypothesis of fear conditioning. Learn Mem 8: 229-242.
• Brot MD, Akwa Y, Purdy RH, Koob GF, Britton KT (1997) The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors. Eur J Pharmacol: 325: 1-7.
• Clugnet MC, LeDoux JE (1990) Synaptic plasticity in fear conditioning circuits: Induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body. J Neurosci 10: 2818-2824.
• Coenen AM (1995) Neuronal activities underlying the elec­troencephalogram and evoked potentials of sleeping and waking: Implications for information processing. Neurosci Biobehav Rev 19: 447-463.
• Coenen AM, van Luijtelaar EL (2003) Genetic animal mod­els for absence epilepsy: A review of the WAG/Rij strain of rats. Behav Genet 33: 635-655.
• Collins DR, Paré D (2000) Differential fear conditioning induces reciprocal changes in the sensory responses of lateral amygdala neurons to the CS(+) and CS(-). Learn Mem 7: 97-103.
• Ehlers CL, Kaneko WM, Wall TL, Chaplin RI (1992) Effects of dizocilpine (MK-801) and ethanol on the EEG and event-related potentials (ERPS) in rats. Neuropharmacology 31: 369-378.
• Ehlers CL, Somes C, Lopez A, Kirby D, Rivier JE (1997) Electrophysiological actions of neuropeptide Y and its analogs: New measures for anxiolytic therapy? Neuropsychopharmacology 17: 34-43.
• Engin E, Treit D (2007) The anxiolytic-like effects of allo- pregnanolone vary as a function of intracerebral microin­fusion site: the amygdala, medial prefrontal cortex, or hippocampus. Behav Pharmacol 18: 461-470.
• Handy TC (2005) Basic principles of ERP quantification. In: Event-Related Potentials: A Methods Handbook (Handy TC, ed.). The MIT Press, Cambridge, MA, p. 33-55.
• Huang YY, Kandel ER (1998) Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygda­la. Neuron 21: 169-178.
• Iwata J, LeDoux JE, Meeley MP, Arneric S, Reis DJ (1986) Intrinsic neurons in the amygdaloid field projected to by the medial geniculate body mediate emotional responses conditioned to acoustic stimuli. Brain Res 383: 195-214.
• Iwata J, LeDoux JE (1988) Dissociation of associative and nonassociative concomitants of classical fear condition­ing in the freely behaving rat. Behav Neurosci 102: 66-76.
• Jeleń P, Zagrodzka J (2001) Heart rate changes in partially restrained rats during behaviorally and pharmacologically evoked emotional states. Acta Neurobiol Exp (Wars) 61: 53-67.
• Knippenberg JMJ, van Luijtelaar ELJM, Maes JHR (2002) Slow late component in conditioned stimulus-evoked potentials from the amygdala after fear conditioning in the rat. Neural Plast 9: 261-272.
• Knippenberg JMJ, Maes JHR, Kuniecki MJ, Buyse BAJ, Coenen AML, van Luijtelaar G (2008) N150 in amygda- lar ERPs in the rat: Is there modulation by anticipatory fear? Physiol Behav 93: 222-228.
• Maren S (1999) Long-term potentiation in the amygdala: A mechanism for emotional learning and memory. Trends Neurosci 22: 561-567.
• Maren S, Quirk GJ (2004) Neuronal signalling of fear memory. Nat Rev Neurosci 5: 844-852.
• McGaugh JL (2004) The amygdala modulates the consolida­tion of memories of emotionally arousing experiences. Annu Rev Neurosci 27: 1-28.
• Paré D, Collins DR (2000) Neuronal correlates of fear in the lateral amygdala: Multiple extracellular recordings in conscious cats. J Neurosci 20: 2701-2710.
• Paxinos G, Watson C (1998) The Rat Brain in Stereotaxic Coordinates (4th edition). Academic Press, San Diego, CA.
• Puia G, Santi MR, Vicini S, Pritchett DB, Purdy RH, Paul SM, Seeburg PH, Costa E (1990) Neurosteroids act on recombinant human GABAA receptors. Neuron 4: 759­765.
• Reddy DS, Kulkarni SK (1997) Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice. Brain Res 752: 61-71.
• Robledo P, Kaneko WM, Ehlers CL (1995) Effects of neuro­tensin on EEG and event-related potentials in the rat. Psychopharmacology (Berl) 118: 410-418.
• Rogan MT, LeDoux JE (1995) LTP is accompanied by com­mensurate enhancement of auditory-evoked responses in a fear conditioning circuit. Neuron 15: 127-136.
• Rogan MT, Stäubli UV, LeDoux JE (1997) Fear condition­ing induces associative long-term potentiation in the amygdala. Nature 390: 604-607.
• Rupprecht R (2003) Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties. Psychoneuroendocrinology 28: 139-168.
• Schafe GE, Doyere V, LeDoux JE (2005) Tracking the fear engram: The lateral amygdala is an essential locus of fear memory storage. J Neurosci 25: 10010-10014.
• Sigurdsson T, Doyere V, Cain CK, LeDoux JE (2007) Long- term potentiation in the amygdala: A cellular mechanism of fear learning and memory. Neuropharmacology 52: 215-227.
• Slawecki CJ, Walpole T, Purdy RH, Ehlers CL (2000) Comparison of the neurophysiological effects of allo- pregnanolone and ethanol in rats. Psychopharmacology (Berl) 149: 351-359.
• Tang J, Wotjak CT, Wagner S, Williams G, Schachner M, Dityatev A (2001) Potentiated amygdaloid auditory- evoked potentials and freezing behavior after fear condi­tioning in mice. Brain Res 919: 232-241.
• Tang J, Wagner S, Schachner M, Dityatev A, Wotjak CT (2003) Potentiation of amygdaloid and hippocampal auditory-evoked potentials in a discriminatory fear-con­ditioning task in mice as a function of tone pattern and context. Eur J Neurosci 18: 639-650.
• Twyman RE, Macdonald RL (1992) Neurosteroid regulation of GABAA receptor single-channel kinetic properties of mouse spinal cord neurons in culture. J Physiol 456: 215-245.
• VaezMousavi SM, Barry RJ, Rushby JA, Clarke AR (2007) Evidence for differentiation of arousal and activation in normal adults. Acta Neurobiol Exp (Wars) 67: 179-186.
• Wilensky AE, Schafe GE, Kristensen MP, LeDoux JE (2006) Rethinking the fear circuit: The central nucleus of the amygdala is required for the acquisition, consolida­tion, and expression of Pavlovian fear conditioning. J Neurosci 26: 12387-12396.

Uwagi

PL

Rekord w opracowaniu