PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2011 | 71 | S |
Tytuł artykułu

The involvement of cholinergic system in nicotine sensitization and cross - sensitization between nicotine and morphine in mice

Autorzy
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The mesolimbic dopamine system, the main neural system mediating sensitization, seems to overlap this mediating reward. Given some data indicating that dopamine neurons are effected by cholinergic neurotransmitters, the aim of present study was to determine the influence of varenicline, a partial α4β2 nicotinic receptor agonist (0.5, 1 and 2 mg/kg) and mecamylamine, a nonselective nicotinic receptor antagonist (0.5, 1 and 2 mg/kg) on behavioural sensitization and cross – sensitization induced by nicotine (0.175 mg/kg, base) and morphine (5 mg/kg) in mice. First, we revealed that repeated injections of nicotine (9 days, every other day) produced significant increase in locomotor activity in mice measured following 7-day withdrowal after injection of challange doses of nicotine and morphine. Subsequently, we found that varenicline and mecamylamine attenuated the acquisition and expression of nicotine sensitization as well as locomotor crosssensitization between nicotine and morphine. Because they had no effects on naive mice, we concluded that the ability of both agents to block this results did not correspond to general supression of activity. The development of nicotine locomotor sensitization shows similarity to relapse described in ex-smokers and cross – sensitization seems to reflect the phenomenon of simultaneous abuse of several different drugs. Our results indicate similar nicotinic neurotransmission - probably through the α4β2 receptor subtypes - involved in the locomotor stimulant effects of nicotine and morphine in mice. This data suggest that cholinergic neurotransmission may be a potential target for developing pharmacotherapeutic strategies to prevent and treat nicotine and/or opioid addiction.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
71
Numer
S
Opis fizyczny
p.75
Twórcy
autor
  • Department of Public Health, University of Information, Technology and Menagement of Rzeszow, Rzeszow, Poland
autor
  • Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland
Bibliografia
Uwagi
Rekord w opracowaniu
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-e7d1d61e-1387-4c7b-9e84-ee376f7e433a
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.