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2009 | 69 | 3 |
Tytuł artykułu

High frequency stimulation of the subthalaic nucleus increases blood NK cell number in hemiparkinsonian rats differing in response to novelty

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
High frequency stimulation (HFS) of the subthalamic nucleus (STN) is a surgical therapy for improving of motor symptoms in Parkinson’s disease. In this study, we assessed the HFS effects on cytometric analysis of the peripheral blood lymphocytes (T, B, NK, T helper, T cytotoxic) in freely moving hemiparkinsonian rats. Before unilateral lesion of the right substantia nigra pars compacta (6-hydroxydopamine), all rats were divided into two behavioral groups: high-HR and low-LR responders in novelty test. As compared to the sham controls, HFS of STN signifi cantly increases NK cell percentage number (25.86 ± 9.68% vs. 18.79 ± 5.63%, P<0.05). In contrast, signifi cantly (P<0.05) lower B lymphocytes level in stimulated (18.86 ± 3.91%) then sham group (22.80 ± 4.63%) was observed. These general changes in NK and B lymphocyte numbers were refl ected in HR stimulated animals (31.08 ± 7.19% vs. 20.44 ± 5.65% for NK cells number and 17.67 ± 2.57% vs. 23.23 ± 3.37% for B lymphocyte, stimulated vs controls, respectively, P<0.01). On the other hand, signifi - cantly lower T lymphocyte level in LR stimulated animals in comparison to LR controls was found (38.32 ± 4.18% vs. 45.91 ± 5.68%). Moreover, signifi cant differences between stimulated HRS and LRS in the NK and T cytotoxic percentages were found (31.08 ± 7.19% vs. 17.63 ± 6.74%, P<0.05; 8.46 ± 1.83% vs. 12.29 ± 1.76%, P<0.01). The results emphasize the importance of individual differences in reactivity to novelty on immune response to HFS of STN.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.344
Twórcy
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
Bibliografia
Typ dokumentu
Bibliografia
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