Onchocerca lupi infection in Turkey: A unique case of a rare human parasite

• Autorzy: Ilhan H.D. , Yaman A. , Morishima Y. , Sugiyama H. , Muto M. , Yamasaki H. , Hasegawa H. , Lebe B. , Bajin M. S.
• Języki publikacji: EN

Abstrakty

EN

Onchocerpa lupi was first isolated from a wolf in Russia. Since then, canine ocular onchocercosis has been increasingly reported, particularly in Europe and the United States. It is thought that blackflies and midges are the vectors of transmission, and it is possible that these vectors could transmit the parasite to humans. The first human case of O. lupi in Turkey was reported in 2011. In this report we present the third human case of O. lupi infection in Turkey. Our patient was a 28-year-old male who displayed a painless, immobile mass under the conjunctiva. The mass measured 10 × 12 mm in size. Pathological examination of the surgically excised tissue was suggestive of infection by a filarial nematode. Subsequently, the parasite was identified as O. lupi through molecular analysis. All of the previously reported cases of O. lupi in both humans and dogs were more symptomatic than in our patient, Onchocerca infection should not be ruled out during the differential diagnosis of the subconjunctival and orbital cystic mass in instances where there is little to no inflammation. It is important to consider biopsy and carry out molecular analysis to identify the parasite.

Słowa kluczowe

EN

Onchocerca lupi; infection; Turkey; zoonotic infection; human parasite; ocular disease; filarial nematode; molecular analysis

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 2013
• Tom: 58
• Numer: 3
• Opis fizyczny: p.384-388,fig.,ref.

Twórcy

autor

Ilhan H.D.

• Department of Ophthalmology, Akdeniz University, Antalya, Turkey

autor

Yaman A.

• Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey

autor

Morishima Y.

• Department of Parasitology, National Institute of Infectious Diseases, Tokyo , Japan

autor

Sugiyama H.

• Department of Parasitology, National Institute of Infectious Diseases, Tokyo , Japan

autor

Muto M.

• Department of Parasitology, National Institute of Infectious Diseases, Tokyo , Japan

autor

Yamasaki H.

• Department of Parasitology, National Institute of Infectious Diseases, Tokyo , Japan

autor

Hasegawa H.

• Department of Biology, Oita University, Oita, Japan

autor

Lebe B.

• Department of Pathology, Dokuz Eylul University, Izmir, Turkey

autor

Bajin M. S.

• Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey

Bibliografia

• Azarova. N.S., Miretskii O.I., Sonin M.D. 1965. The first instance of detection of nematode Onchocerca Diesing, 1841 in a person in the USSR. Medical Parazitology, 34, 156–158 (in Russian).
• Burr W.E. Jr., Brown M.F., Eberhard M.L. 1998. Zoonotic Onchocerca (Nematoda: Filarioidea) in the cornea of a Colorado resident. Ophthalmology, 105(8), 1494–1497.
• Dang T.C.T., Nguyen T.H., Do T.D., Uga S., Morishima Y., Sugiyama H., Yamasaki H. 2010. A human case of subcutaneous dirofilariasis caused by Dirofilaria repens in Vietnam: histologic and molecular confirmation. Parasitology Research, 107, 1003–1007.
• Eberhard M.L., Ortega Y., Dial S., Schiller C.A., Sears A.W., Greiner E. 2000. Ocular Onchocerca infections in western United States. Veterinary Parasitology, 90, 333–338.
• Orihel T.C., Ash L.R., Holshuh H.J., Santenelli S. 1991. Onchocerciasis in a California dog. American Journal of Tropical Medicine and Hygiene, 44, 513–517.
• Otranto D., Sakru N., Testini G., Gürlü V.P., Yakar K., Lia R.P., Dantas-Torres F., Bain O. 2011. Case report: First evidence of human zoonotic infection by Onchocerca lupi (Spirurida, Onchocercidae). American Journal of Tropical Medicine and Hygiene, 84, 55–58. DOI: 10.4269/ajtmh.2011.10-0465.
• Otranto D., Dantas-Torres F., Cebeci Z., Yeniad B., Buyukbabani N., Boral O.B., Gustinelli A., Mounir T., Mutafchiev Y., Bain O. 2012. Human ocular onchocerciasis: further evidence on the zoonotic role of Onchocerca lupi. Parasites & Vectors, 5, 84. DOI: 10.1186/1756-3305-5-84.
• Pampiglione S., Vakalis N., Lyssimachou A., Kouppari G., Orihel T.C. 2001. Subconjunctival zoonotic Onchocerca in an Albanian man. Annals of Tropical Medicine & Parasitology, 95, 827–832.
• Rodonaja T.E. 1967. A new species of nematode, Onchocerca lupi n. sp., from Canis lupus cubanensis. Soobshcheniya Akademii Nauk Gruzinskoy SSR, 45, 715–719 (in Russian).
• Sallo F., Eberhard M.L., Fok E., Baska F., Hatvani I. 2005. Zoonotic intravitreal Onchocerca in Hungary. Ophthalmology, 112, 502–504.
• Sréter T., Széll Z. 2008. Onchocercosis: a newly recognized disease in dogs. Veterinary Parasitology, 151, 1–13.