Morphometric characteristics of the small and large intestines of Mus musculus during postnatal development

• Autorzy: Wolczuk K. , Wilczynska B. , Jaroszewska M. , Kobak J.
• Języki publikacji: EN

Abstrakty

EN

The objective of this study was to investigate the size of the small and large intestine in postnatal development of Mus musculus mice. The gut was obtained from 2-, 4-, 6-, and 12-week-old animals. The morphometric analysis was performed at microscopic level. Measurements and calculations included dimensions of villi (height, diameter) and their number per 1 mm² surface area in the proximal, middle, and distal section of the small intestine, as well as the length and surface area (external and internal) of the small and large intestines. To find the allometric relationship between the size of the small and large intestines and body mass, reduced major axis regression was applied. The length and surface area of both intestinal segments gradually increased with age. The increase in the internal surface area of the small intestine was the result of lengthening of the intestine and increasing diameter of the villi in its proximal and middle sections. No increase in villus height during the studied period was detected. A marked increase in the size of the intestinal segments was observed between the 2nd and 4th weeks of life, when the length doubled and the surface area tripled in size. Allometric analysis revealed that the increase in length and internal surface area of the small and large intestines was more rapid than the body mass increase during the weaning period, while it was not different from isometry after the weaning. In conclusion, the greatest changes in the structure and size of the small and large intestines of mice occurred in the weaning period. During this period these two segments of intestine grew faster than the rest of the body and reached adult proportions. (Folia Morphol 2011; 70, 4: 252–259)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2011
• Tom: 70
• Numer: 4
• Opis fizyczny: p.252-259,ref.

Twórcy

autor

Wolczuk K.

• Laboratory of Histology and Embryology of Vertebrates, Institute of Ecology and Environment Protection, Faculty of Biology and Earth Sciences, Nicolaus Copernicus University, Gagarina 9, 87-100 Torun, Poland

autor

Wilczynska B.

• Laboratory of Histology and Embryology of Vertebrates, Institute of Ecology and Environment Protection, Faculty of Biology and Earth Sciences, Nicolaus Copernicus University, Torun, Poland

autor

Jaroszewska M.

• Laboratory of Histology and Embryology of Vertebrates, Institute of Ecology and Environment Protection, Faculty of Biology and Earth Sciences, Nicolaus Copernicus University, Torun, Poland

autor

Kobak J.

• Department of Invertebrate Zoology, Institute of General and Molecular Biology, Faculty of Biology and Earth Sciences, Nicolaus Copernicus University, Torun, Poland

Bibliografia

• 1. Buddington RK, Diamond J (1992) Ontogenic development of nutrient transporters in cat intestine. Am J Physiol, 263: G605–G616.
• 2. Buts JP, De Meyer R (1981) Postnatal proximodistal development of the small bowel mucosal mass in growing rats. Biol Neonate, 40: 62–69.
• 3. Cummins AG, Thompson FM (2002) Effect of breast milk and weaning on epithelial growth of the small intestine in humans. Gut, 51: 748–754.
• 4. Ferraris RP (1994) Regulation of intestinal nutrient transport. In: Johnson R ed. Physiology of the gastrointestinal tract. Raven Press, New York, pp. 1821–1843.
• 5. Ginneken C, Meir F, Weyns A (2002) Stereologic characteristics of pig small intestine during normal development. Dig Dis Sci, 47: 868–887.
• 6. Goodland RA, Wright NA (1990) Changes in intestinal cell proliferation, absorptive capacity and structure in young, adult and old rats. J Anat, 173: 109–118.
• 7. Kelly D, Smyth JA, McCracken KJ (1991) Digestive development of the early-weaned pig. Br J Nutr, 65: 169–180.
• 8. Kiso Y, Oku K, Yamauchi S (1988) Prenatal and postnatal development of small intestine in the insectivore Suncus murinus. Am J Anat, 183: 57–67.
• 9. Kramer DL, Bryant MJ (1995) Intestine length in the fishes of a tropical stream: 1. Ontogenetic allometry. Environ Biol Fish, 42: 115–127.
• 10. Lawrence LA, Lawrence JT (2009) Gastrointestinal tract development of the equine. In: Pagan JD ed. Advances in equine nutrition IV. Nottingham University Press, Nottingham, pp. 173–183.
• 11. Lentle RG, Dey D, Hulls C, Mellor DJ, Moughan PJ, Stafford KJ, Nicholas K (2006) Quantitative study of the morphological development and bacterial colonisation of the gut of the tammar wallaby Macropus eugenii eugenii and brushtail possum Trichosurus vulpecula during in-pouch development. J Comp Physiol B Biochem Syst Environ Physiol, 176: 763–774.
• 12. Lu X, Zhao J, Gregersen H (2005) Small intestinal morphometric and biomechanical changes during physiological growth in rats. J Biomech, 38: 417–426.
• 13. McArdle BH (1987) The structural relationship: regression in biology. Can J Zool, 66: 2329–2339.
• 14. Mitjans M, Ferrer R (2004) Morphometric study on the guinea pig small intestine during development. Microsc Res Tech, 63: 206–214.
• 15. Paulsen DR, Buddington KK, Buddington RK (2003) Dimensions and histologic characteristics of the small intestine of dogs during postnatal development. Am J Vet Res, 64: 618–626.
• 16. Sabatakou O, Xylouri-Frangiadaki E, Paraskevakou E, Papantonakis K (1999) Scanning electron microscopy of stomach and small intestine of rabbit during foetal and post natal life. J Submicrosc Cytol Pathol, 31: 107–114.
• 17. Sakata T (2002) Allometric growth of the small and large intestine of rats before and after weaning. In: Zabielski R, Gregory PC, Weström B ed. Biology of the intestine in growing animals. Elsevier Science, Philadelphia, pp. 221–233.
• 18. Sakata T, Setoyama H (1997) Bi-phasic allometric growth of the small intestine, cecum and the proximal, middle and distal colon of rats (Rattus norvegicus Berkenhout, 1764) before and after weaning. Comp Biochem Physiol A Physiol, 118: 897–902.
• 19. Smyth GB (1988) Effects of age, sex and post mortem interval on intestinal lengths of horses during development. Equine Vet J, 20: 104–108.
• 20. Thomson ABR, Keelan M (1986) The development of the small intestine. Can J Physiol Pharmacol, 64: 13–29.
• 21. Toloza EM, Diamond J (1992) Ontogenic development of nutrient transporters in rat intestine. Am J Physiol (Gastrointest Liver Physiol), 263: G593–G604.
• 22. Vigueras RM, Rojas-Castaneda J, Hernández R, Reyes G (1999) Histological characteristics of the intestinal mucosa of the rat during the first year of life. Lab Anim, 33: 393–400.
• 23. Walthall K, Cappon GD, Hurtt ME, Zoetis T (2005) Postnatal Development of the gastrointestinal system: A species comparision. Birth Defects Res (Part B), 74: 132–156.
• 24. Wang L, Li J, Li Q, Zhang J, Duan XL (2003) Morphological changes of cell proliferation and apoptosis in rat jejunal mucosa at different ages. World J Gastroenerol, 9: 2060–2064.
• 25. Weaver CM, Heaney RP, Martin BR, Fitzsimmons ML (1991) Human calcium absorption from whole wheat products. J Nutr, 121: 1769–1775.
• 26. Weibel E, Taylor C, Hoppeler H (1991) The concept of symmorphosis: a testable hypothesis of structure–function relationship. Proc Natl Acad Sci USA, 88: 10357–10361.
• 27. Weibel E, Taylor C, Gehr P, Hoppeler H, Mathieu O, Maloiy G (1981) Design of the mammalian respiratory system. IX. Functional and structural limits for oxygen flow. Resp Physiol, 44: 151–164.
• 28. Yu B, Chiou WS (1997) The morphological changes of intestinal mucosa in growing rabbits. Lab Anim, 31: 254–263.

Uwagi

rekord w opracowaniu