Transcription factor SRF controls neuronal plasticity
Gene expression induced by neuronal activity is essential for the establishment of long-lasting changes in synaptic connectivity. The cell nucleus, where an active gene transcription occurs, plays the key role as a signal integrator. Transcription factors controlling process of physiological and pathological plasticity remain underinvestigated. This presentation will focus on our recent studies showing that Serum Response Factor, SRF plays a prominent role in regulating expression of genes during development and adult neuronal plasticity. Using genome-wide approach, we identified transcription program regulated by SRF and identified genes that may function as “molecular brakes” giving negative feedback in response to strong neuronal stimulation. Thus, the lack of SRF could contribute to the development of hyperexcitability associated disorder like epilepsy. Moreover, the role of SRF in the regulation of structural and physiological plasticity during development will be discussed. FINANCIAL SUPPORT: Supported by Polish National Science Center grant (SONATA BIS 2) DEC-2012/07/E/ NZ3/01814.