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2017 | 77 | Suppl.1 |
Tytuł artykułu

The effect of norepinephrine on the rat intergeniculate leaflet neurons – An in vitro electrophysiological study

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
INTRODUCTION: The intergeniculate leaflet (IGL) is an important structure of the circadian timing system, involved in the integration of photic and non-photic information. The IGL receives input from the retina, as well as from many non‑specific projections of the brainstem, which provide it with all the non-photic information needed for synchronization of circadian rhythmicity. One of the non‑specific projections is the norepinephrine system, extending from the locus coeruleus throughout the brain. Norepinephrine in the central nervous system is involved in the mechanism of arousal, and therefore enhance cognitive processes such as attention and memory. However, how it regulates the circadian system via the IGL has not yet been described. AIM(S): The aim of the study was to determine whether and how the norepinephrine (NE) can modulate the activity of single IGL neurons. METHOD(S): The method used in this experiment was a whole-cell patch clamp on brain slices from 2/3-week-old Wistar rats. Norepinephrine and tetrodotoxin (TTX) were applied by bath perfusion. After each experiment, slices were immunostained to verify the localization of the recorded cell in the IGL. RESULTS: Both depolarization and hyperpolarization of the IGL neurons were observed after NE application. In most cases the effect was postsynaptic, however, there were also a few cells which showed no direct response after norepinephrine application in the TTX solution. CONCLUSIONS: Norepinephrine elicits different effects on IGL neuronal activity. The expression of different types of noradrenergic receptors in IGL cells’ membrane could be a reason for such various types of responses. We believe that NE acts in the IGL as an activity modulator, which regulates its responses to other cues. To our knowledge, this is the first study analyzing the effect of norepinephrine on IGL neuronal activity. FINANCIAL SUPPORT: This work is supported by grant obtained from the Institute of Zoology: DS/MND/WBiNoZ/ IZ/29/2016.
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Wydawca
-
Rocznik
Tom
77
Numer
Opis fizyczny
p.96
Twórcy
autor
  • Jagiellonian University, Departament of Neurophysiology and Chronobiology, Cracow, Poland
autor
  • Jagiellonian University, Departament of Neurophysiology and Chronobiology, Cracow, Poland
autor
  • Jagiellonian University, Departament of Neurophysiology and Chronobiology, Cracow, Poland
  • Jagiellonian University, Departament of Neurophysiology and Chronobiology, Cracow, Poland
Bibliografia
Typ dokumentu
Bibliografia
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Identyfikator YADDA
bwmeta1.element.agro-debf4e90-e296-40f3-872b-5b31d25a396d
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