Dynamic changes in mouse hippocampal gene expression during chronic stress

• Autorzy: Stankiewicz A.M. , Goscik J. , Juszczak G. R. , Majewska A. , Swiergiel A. H. , Lisowski P.
• Języki publikacji: EN

Abstrakty

EN

Transcriptome profiling of chronic social stress (CSS) effects on the brain revealed changes in expression of many genes responsible for alterations of structure and function of the central nervous system. However, there is still little information on dynamics of gene expression in the brain during chronic stress. The aim of the study was to investigate the time course of mouse hippocampal transcriptome response in CSS. Gene expression was assessed using Agilent microarrays. Number of genes showed specific expression patterns between CSS and control animals during subsequent time points, including genes involved in glutamate transport (Slc17a6), amyloid sequestration (Ttr) and neuroprotection (Igf2, Igfbp2). Study revealed dynamics of gene expression patterns and novel molecular effectors of behavioral effects of stress.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.50

Twórcy

autor

Stankiewicz A.M.

• Insitute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland

autor

Goscik J.

• Department of Software Engineering, Bialystok Technical University, Poland

autor

Juszczak G. R.

• Insitute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland

autor

Majewska A.

• Department of Physiological Sciences, Warsaw University of Life Sciences, Warsaw, Poland

autor

Swiergiel A. H.

• Insitute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland
• Department of Biology, Gdansk University, Gdansk, Poland

autor

Lisowski P.