PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2009 | 69 | 3 |
Tytuł artykułu

Reinforcement of en early-LTP in the hipocampall CAI by stimulation of the ventral tegmental area in freely moving rats

Autorzy
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
It has been shown that the prolonged maintenance of hippocampal long-term potentiation (LTP) requires heterosynaptic events during its induction. The ventral tegmental area (VTA), a modulatory input to the CA1 region is a heterogeneous group of dopaminergic cells and a major component of the mesolimbic dopamine system. We used a method which allowed us to simultaneously record both, the fi eld-EPSP and the population spike (POP) in the hippocampal CA1 in freely moving rats by stimulation of the contralateral CA3. We could show that an early-LTP in the CA1 region can be reinforced into a longer-lasting form by high-frequency stimulation of the VTA 15 min after its induction. This reinforcement of an early-LTP in CA1 was dependent on dopaminergic receptor activation and was also dependent on protein synthesis. We have now extended our studies and could show that high-frequency stimulation of the VTA alone, i.e. without LTP-induction in CA1, caused a delayed-onset potentiation for the recorded fi eld-EPSP and POP in the CA1 region in response to test stimulation of the contralateral CA3. This delayedonset potentiation was dependent on the synergistic activation of both the glutamatergic and the dopaminergic receptor activation, because paused glutamatergic test stimulation abolished this potentiation.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.333
Twórcy
autor
  • Department of Neurophysiology, Leibniz Institute for Neurobiology, Magdeburg, Germany
autor
  • Department of Neurophysiology, Leibniz Institute for Neurobiology, Magdeburg, Germany
autor
  • Department of Neurophysiology, Leibniz Institute for Neurobiology, Magdeburg, Germany
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-db3891af-36fb-4923-93be-4807dc731765
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.