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Liczba wyników
2009 | 69 | 3 |
Tytuł artykułu

Prophylactic use of desupramine in wistar rats with high stress-sensitivity increases resistance to experimental tumor metastasis

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The effect of antidepressant drugs on tumour progress in animals models of stress is very poorly recognized. Further more a role of susceptibility to stress in modulatory effect of antidepressant drug on tumour growth have not been studied. The aim of present study was to establish the effect of individual reactivity to stress and prophylactic two weeks desipramine administration on metastatic colonization of MADB 106 cells in lungs of Wistar rats. Rats were subjected by three weeks to chronic mild stress (CMS) model of depression and high-reactive and non-reactive rats were selected. Three months after CMS termination high-reactive and non-reactive animals were further subdivided: for two additional weeks the rats received daily injection of desipramine or saline. Tumor cells were injected two hours after last desipramine or saline administration. In stress-reactive, vehicle treated rats increase of number of lung metastasis in comparison to stress non-reactive, vehicle treated rats were observed. On the other hand chronic desipramine pretreatment signifi cantly increased survival rate and diminished number of lung metastasis in stress-sensitive animals although did not show such effect in stressresistant animals. Increase in rate of animal survival and decrease in lung metastasis can be connected with stimulatory effect of chronic desipramine pretreatment on NK cell activity. This study was supported by grant N40109732/2074 from Poland’s MS and HE.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.357
Twórcy
autor
  • Department of Experimental Neuroendocrinology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
autor
  • Department of Experimental Neuroendocrinology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
autor
  • Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
  • Department of Experimental Neuroendocrinology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
  • Department of Experimental Neuroendocrinology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
  • Department of Experimental Neuroendocrinology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
autor
  • Department of Experimental Neuroendocrinology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
autor
  • Department of Pain Treatment and Palliative Care, Jagiellonian University Medical College, Krakow, Poland
autor
  • Department of Pain Treatment and Palliative Care, Jagiellonian University Medical College, Krakow, Poland
autor
  • Department of Experimental Neuroendocrinology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
Bibliografia
Typ dokumentu
Bibliografia
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Identyfikator YADDA
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