Behavioral and biochemical effects of acutely administered MDMA in animal models

• Autorzy: Budzynska B. , Boguszewska-Cubara A. , Kruk-Slomka M. , Biala G.
• Języki publikacji: EN

Abstrakty

EN

3,4-Methylenedioxymethamphetamine (MDMA, ‘ecstasy’), a potent monoamine-releaser that is widely used as a recreational drug. Hence, understanding the effects and mechanisms of MDMA is of immense importance for the public health in the world. We examined how an acute dose of MDMA affects memory and learning processes, anxiety- and depressive-like behaviors in female Swiss mice as well as oxidative processes in brain. The aim of the present study was to examine the effects of MDMA (20–0.1 mg/kg, ip) in the forced swim test (FST), elevated plus maze (EPM) and passive avoidance (PA) paradigm in mice. At first, we showed that MDMA at the doses of 10 and 2.5 mg/kg exhibited a significant reduction of immobility time in the FST, indicating the antidepressant-like activity. In the second series of our experiment, we demonstrated that MDMA at the doses of 5 and 2.5 mg/kg improved consolidation of memory processes in PA test. Also, this compound showed strong anxiogenic effect at the range of doses (20–0.5 mg/kg). MDMA at the higher doses (20-5 mg/kg) enhanced oxidative stress, expressed as superoxide dismutase activity, ascorbic acid concentration and malondialdehyde level, within brain, whereas its lower doses did not affect measured parameters. Taken together, these data suggest an anxiogenic-like, antidepresive and procognitive in consolidation trial effects of acute MDMA treatment. The results of our study also showed the influence of MDMA on the oxidative stress processes in the brain.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.364

Twórcy

autor

Budzynska B.

• Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland

autor

Boguszewska-Cubara A.

• Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland

autor

Kruk-Slomka M.

• Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland

autor

Biala G.

• 1Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland