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2023 | 74 | 4 |

Tytuł artykułu

Bio-demographic characteristics of households and risk factors for Down Syndrome in Morocco

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Background. The most studied risk factors for Down Syndrom (DS) were: region of residence, exposure to chemicals, parents’ education level, cigarette and alcohol use by father or mother or both, and oral contraceptive (OC) use. Objective. The aim of this study was to compare certain variables considered as risk factors on DS such as parental age at birth, OC use, child’s sex, and rank of birth between children with DS and their siblings without DS as well as to determine the socio-bio-demographic characteristics of the families studied compared with the general Moroccan population. Material and Methods. We conducted a cross-sectional analysis of 277 families with 925 siblings and at least one child with DS (279 with DS) between 2014 and 2017. The data are collected using a standardized questionnaire in Marrakech- Safi region. Data were entered and analyzed using the statistical program SPSS statistics software for Windows (version 20.0). Chi-square (χ2) and Student t tests were used for testing statistical significance. Differences were considered significant when the p-value <0.05. Results. The binary logistic regression analysis between DS and non-DS children in their bio-demographic characteristics studied (sex, maternal age at birth, paternal age at birth, oral contraceptive (OC) use, length of oral contraceptive use before pregnancy and rank of birth) showed that only maternal age and paternal age at birth and OC use were associated with DS birth (OR= 1.16; 95% CL: 1.11-1.21, OR= 1.05; 95%CL: 1.01-1.09 and OR= 0.01; 95%CL: 0.00-0.003, respectively). In the other hand, the comparison between socio and bio-demographic characteristics of households studied with data from National Population Survey and Family health (2018) showed a higher level of education in women and men in our sample. Similar results were shown in rate of men and women in paid employment, the rate of smoking and alcohol consumption among men and the rate of OC use before pregnancy among women. Conclusion. These results will help to sensitize the Moroccan population about risk factors for DS.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

74

Numer

4

Opis fizyczny

p.415-420,ref.

Twórcy

autor
  • Laboratory of Biotechnology, Biochemistry and Nutrition, Training and Research Unit on Nutrition and Food Sciences, Department of Biology, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24-000, Morocco
autor
  • Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Department of Biology, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakesh, Morocco
autor
  • Laboratory of Biotechnology, Biochemistry and Nutrition, Training and Research Unit on Nutrition and Food Sciences, Department of Biology, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24-000, Morocco
autor
  • Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Department of Biology, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakesh, Morocco

Bibliografia

  • 1. Down JL. Observations of an ethnic classification of idiots. Clin Lect Rep London Hosp 1866;13:121–123. https://doi.org/10.1192/bjp.13.61.121.
  • 2. Jacobs PA, Baikie AG, Court Brown WM, Strong JA. The somatic chromosomes in Mongolism. Lancet 1959;1:710.https://doi.org/10.1016/S0140-6736(59)91892-6.
  • 3. Lejeune J. Le Mongolisme, premier exemple d’aberration autosomique humaine. Ann Genet 1959 ;1:41–49.
  • 4. Antonarakis SE, Down Syndrome Collaborative Group. Parental origin of the extra chromosome in trisomy 21 as indicated by analysis of DNA polymorphisms. N Engl J Med 1991;324:872–876. https://doi.org/10.1056/NEJM199103283241302.
  • 5. Allen EG, Freeman SB, Druschel C, Hobbs CA, O’Leary LA, Romitti PA, et al. Maternal age and risk for trisomy 21 assessed by the origin of chromosome nondisjunction: a report from the Atlanta and National Down Syndrome Projects. Hum 2009;125:41–52. https://doi.org/10.1007/s00439-008-0603-8.
  • 6. Malini SS, Ramachandra NB. Possible risk factors for Down syndrome and sex chromosomal aneuploidy in Mysore, South India. Indian Journal of Human Genetics 2007;13:102–108. https://doi.org/10.4103/0971-6866.38984.
  • 7. Ghosh S, Hong CS, Feingold E, Ghosh P, Ghosh P, Bhaumik P, et al. Epidemiology of Down syndrome: New Insight Into the Multidimensional Interactions Among Genetic and Environmental Risk Factors in the Oocyte. Am J Epidemiol 2011;174(9):1009–1016. https://doi.org/10.1093/aje/kwr240.
  • 8. Shalaby HMA. A study of new potential risk factors for Down syndrome in Upper Egypt. The Egyptian Journal of Medical Human Genetics 2011;12, 15–19.
  • 9. Martínez-Frías ML, Bermejo E, Rodríguez-Pinilla E, Prieto L. Periconceptional exposure to Contraceptive Pills and Risk for Down Syndrome. Journal of Perinatology 2001;21:288 – 292. https://doi.org/10.1038/sj.jp.7210538.
  • 10. Nagy GR, Győrffy B, Nagy B, Rigó Jr J. Lower risk for Down syndrome associated with longer oral contraceptive use: a case-control study of women of advanced maternal age presenting for prenatal diagnosis. Contraception 2012;87:455–458. https://doi.org/10.1016/j.contraception.2012.08.040.
  • 11. Ray A, Hong CS, Feingold E, Ghosh P, Ghosh P, Bhaumik P, et al. Maternal Telomere Length and Risk of Down Syndrome: Epidemiological Impact of Smokeless Chewing Tobacco and Oral Contraceptive on Segregation of Chromosome 21. Public Health Genomics 2016; 19:11–18
  • 12. Horányi1 D, Babay LÉ, Rigó JJr., Győrffy B, Nagy GR: Effect of extended oral contraception use on the prevalence of fetal trisomy 21 in women aged at least 35 years. Int J Gynecol Obstet 2017; 138: 261–266
  • 13. World Health Organization. Neonatal and Perinatal Mortality: Country, Regional and Global Estimates. Geneva, Switzerland. World Health Organization 2006. https://apps.who.int/iris/handle/10665/43444.
  • 14. ENPSF. Enquête Nationale sur la Population et la Santé Familiale 2018. Ministère de la Santé Publique, Royaume du Maroc.
  • 15. ENJ. Enquête Nationale sur les Jeunes 2011, rapport de synthèse. Haut–Commissariat au Plan. Royaume du Maroc. Accessed on 10/8/2023 https://www.hcp.ma/downloads/Enquete-nationale-sur-les-jeunes_t22388.html
  • 16. Yoon PW, Freeman SB, Sherman SL, Taft LF, Gu Y, Pettay D, et al. Advanced Maternal Age and the Risk of Down Syndrome Characterized by the Meiotic Stage of the Chromosomal Error: A Population-Based Study. Am. J. Hum. Genet 1996; 58:628-633.
  • 17. Gaulden ME. Maternal age effect: The enigma of Down syndrome and other trisomic conditions. Mutation Research 1992;296: 69-88
  • 18. Laignier MR, Lopes-Júnior LC, Santana RE, Leite FMC, Brancato CL. Down Syndrome in Brazil: Occurrence and Associated Factors. Int. J. Environ. Res. Public Health 2021;18(22), 11954; https://doi.org/10.3390/ijerph182211954
  • 19. Fisch H, Hyun G, Golden R, Hensle TW, Olsson CA, Liberson GL. The influence of paternal age on Down syndrome. J Urol 2003;169:2275–2278. https://doi.org/10.1097/01.ju.0000067958.36077.d8.
  • 20. Dzurova D, Pikhart H. Down syndrome, paternal age and education: comparison of California and the Czech Republic. BMC Public Health 2005;5:69 doi:10.1186/1471-2458-5-69
  • 21. Stene J, Stene E, Stengel-Rutkowski S, Murken JD. Paternal Age and Down’s Syndrome Data from Prenatal Diagnoses (DFG). Hum Genet 1981; 59:119-124
  • 22. Buwe A, Guttenbach M, Schmid M. Effect of paternal age on the frequency of cytogenetic abnormalities in human spermatozoa. Cytogenet Genome Res 2005;111:213–228. https://doi.org/10.1159/000086892.
  • 23. Thompson JA. Disentangling the roles of maternal and paternal age on birth prevalence of Down syndrome and other chromosomal disorders using a Bayesian modeling approach. Thompson BMC Medical Research Methodology 2019;19:82 https://doi.org/10.1186/s12874-019-0720-1.
  • 24. Jaouad IC, Cherkaoui Deqaqi S, Sbiti A, Natiq A, Elkerch A, Sefiani F. Cytogenetic and epidemiological profiles of Down syndrome in a Moroccan population: a report of 852 cases. Singapore Med J 2010;51(2):133–136.
  • 25. Hunter JE, Allen EG, Shin M, Bean LJ, Correa A, Druschel C, et al. The association of low socioeconomic status and the risk of having a child with Down syndrome: a report from the National Down Syndrome Project. Genetics in medicine 2013;15(9):698-705
  • 26. Corona-Rivera JR, Martínez-Macías FJ, Bobadilla-Morales L, Corona-Rivera A, Peña-Padilla C, Rios-Flores IM, et al. Prevalence and risk factors for Down syndrome : A hospital-based single-center study in Western Mexico. Am J Med Genet 2019; 1–7
  • 27. Rezayat AA, Nazarabadi MH, Andalibi MS, Ardabili HM, Shokri M, Mirzaie S and Jarahi L. Down syndrome and consanguinity. J Res Med Sci 2013;18:995-7.
  • 28. Jaouad IC, Elalaoui SC, Sbiti A, Elkerh F, Belmahi L, Sefiani A. Consanguineous marriages in Morocco and the consequence for the incidence of autosomal recessive disorders. J. Biosoc. Sci. 2009;41(5):575–581
  • 29. Ray A, Oliver TR, Halder P, Pal U, Sarkar S, Dutta S, et al. Risk of Down syndrome birth: Consanguineous marriage is associated with maternal meiosis-II nondisjunction at younger age and without any detectable recombination error. Am J Med Genet 2018;1–8.

Typ dokumentu

Bibliografia

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