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2011 | 58 | 4 |
Tytuł artykułu

Vitamin K status in peritoneally dialyzed patients with chronic kidney disease

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Abnormal vitamin K status was documented in patients with chronic kidney diseases (CKD), especially those undergoing hemodialysis. The data related to patients undergoing peritoneal dialysis (PD) are contradictory. Therefore, in the present study we aimed to evaluate vitamin K status in patients with CKD who are treated with continuous ambulatory PD. Twenty-eight patients entered into the study. Dialysis vintage ranged from 3 to 89 months. Vitamin K status was assessed in all subjects using undercarboxylated prothrombin measurement (PIVKA-II). In addition, total protein and albumin levels, total cholesterol, LDL cholesterol, triglyceride, calcium, urea and creatinine concentrations were determined. PIVKA-II concentrations were abnormal in 13 (46.4 %) subjects. BMI values, both total and LDL cholesterol concentrations were significantly higher in patients with than those without vitamin K deficiency. Moreover, PIVKA II levels correlated with BMI values (r = 0.441, p < 0.019), LDL cholesterol (r = 0.434, p < 0.021) and creatinine (r = 0.406, p < 0.032) concentrations. However, through the use of logistic regression analysis and multiple regression analysis, no clinical factor was documented to be the independent risk factor of vitamin K deficiency. In conclusion, vitamin K deficiency is a frequent condition in peritoneally dialyzed patients. Assessment of vitamin K status should become a standard procedure in this group of patients.
Wydawca
-
Rocznik
Tom
58
Numer
4
Opis fizyczny
Twórcy
  • Department of Internal Medicine, Metabolism and Dietetics, Poznan University of Medical Sciences, Poznan, Poland
autor
autor
autor
Bibliografia
  • Danziger J (2008) Vitamin K-dependent proteins, warfarin, and vascular calcification. Clin J Am Soc Nephrol 3: 1504-1510. 
  • Fouque D, Vennegoor M, ter Wee P, Wanner C, Basci A, Canaud B, Haage P, Konner K, Kooman J, Martin-Malo A, Pedrini L, Pizzarelli F, Tattersall J, Tordoir J, Vanholder R (2007) EBPG guideline on nutrition. Nephrol Dial Transplant. 22 Suppl 2: ii45-ii87. 
  • Fusaro M, Crepaldi G, Maggi S, Galli F, D'Angelo A, Calò L, Giannini S, Miozzo D, Gallieni M (2011) Vitamin K, bone fractures, and vascular calcifications in chronic kidney disease: an important but poorly studied relationship. J Endocrinol Invest 34: 317-323. 
  • Holden R, Iliescu E, Morton AR, Booth SL (2008) Vitamin K status of Canadian peritoneal dialysis patients. Perit Dial Int 28: 415-418. 
  • Holden RM, Morton AR, Garland JS, Pavlov A, Day AG, Booth SL (2010) Vitamins K and D status in stages 3-5 chronic kidney disease. Clin J Am Soc Nephrol 5: 590-597. 
  • Krueger T, Westenfeld R, Ketteler M, Schurgers LJ, Floege J (2009) Vitamin K deficiency in CKD patients: a modifiable risk factor for vascular calcification? Kidney Int 76: 18-22. 
  • Małyszko J, Wołczyński S, Skrzydlewska E, Małyszko JS, Myśliwiec M (2002) Vitamin K status in relation to bone metabolizm in patients with renal failure. Am J Nephrol 22: 504-508. 
  • Małyszko JS, Małyszko J, Skrzydlewska E, Pawlak K, Myśliwiec M (2004) Protein Z and vitamin K in kidney disease. Rocz Akad Med Białymst 49: 197-200. 
  • Nagasawa Y, Fujii M, Kajimoto Y, Imai E, Hori M (1998a) Vitamin K2 and serum cholesterol in patients on continuous ambulatory dialysis. Lancet 351: 724.  
  • Nagasawa Y, Fujii M, Kajimoto Y, Imai E, Hori M (1998b) bis Vitamin K supplementation in patients on continuous ambulatory peritoneal dialysis. Lancet 352: 1735. Authors reply.
  • Nerlander M, Voong K, Manghat P, Hampson G, Harrington D, Shearer M, Goldsmith D (2009) Subclinical deficiency of vitamin K status in chronic kidney disease. World Congress of Nephrology (Poster session), Milan, May 22-26.
  • Pilkey RM, Morton AR, Boffa MB, Noordhof C, Day AG, Su Y, Miller LM, Koschinsky ML, Booth SL (2007) Subclinical vitamin K deficiency in hemodialysis patients. Am J Kidney Dis 49: 432-439. 
  • Schlieper G, Westenfeld R, Krüger T, Cranenburg EC, Magdeleyns EJ, Brandenburg VM, Djuric Z, Damjanovic T, Ketteler M, Vermeer C, Dimkovic N, Floege J, Schurgers L (2011) Circulating nonphosphorylated carboxylated matrix Gla protein predicts survival in ESRD. J Am Soc Nephrol 22: 387-395. 
  • Vychytil A, Druml W (1998) Vitamin K supplementation in patients on continuous ambulatory peritoneal dialysis. Lancet 351: 1734-1735. 
Typ dokumentu
Bibliografia
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