microRNAs fine tuning of erythropoiesis

• Autorzy: Listowski M.A. , Heger E. , Boguslawska D. M. , Machnicka B. , Kuliczkowski K. , Leluk J. , Sikorski A. F.
• Języki publikacji: EN

Abstrakty

EN

Cell proliferation and differentiation is a complex process involving many cellular mechanisms. One of the best-studied phenomena in cell differentiation is erythrocyte development during hematopoiesis in vertebrates. In recent years, a new class of small, endogenous, non-coding RNAs called microRNAs (miRNAs) emerged as important regulators of gene expression at the post-transcriptional level. Thousands of miRNAs have been identified in various organisms, including protozoa, fungi, bacteria and viruses, proving that the regulatory miRNA pathway is conserved in evolution. There are many examples of miRNA-mediated regulation of gene expression in the processes of cell proliferation, differentiation and apoptosis, and in cancer genesis. Many of the collected data clearly show the dependence of the proteome of a cell on the qualitative and quantitative composition of endogenous miRNAs. Numerous specific miRNAs are present in the hematopoietic erythroid line. This review attempts to summarize the state of knowledge on the role of miRNAs in the regulation of different stages of erythropoiesis. Original experimental data and results obtained with bioinformatics tools were combined to elucidate the currently known regulatory network of miRNAs that guide the process of differentiation of red blood cells.

Słowa kluczowe

EN

microRNA; erythropoiesis; cell proliferation; cellular mechanism; cell differentiation; erythrocyte; hematopoiesis; vertebrate; gene expression; cancer; genesis; erythroid

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2013
• Tom: 18
• Numer: 1
• Opis fizyczny: p.34-46,fig.,ref.

Twórcy

autor

Listowski M.A.

• Department of Molecular Biology, University of Zielona Gora, Zielona Gora, Poland

autor

Heger E.

• Department of Molecular Biology, University of Zielona Gora, Zielona Gora, Poland

autor

Boguslawska D. M.

• Department of Molecular Biology, University of Zielona Gora, Zielona Gora, Poland

autor

Machnicka B.

• Department of Molecular Biology, University of Zielona Gora, Zielona Gora, Poland

autor

Kuliczkowski K.

• Department of Hematology, Medical University of Wroclaw, Poland

autor

Leluk J.

• Department of Molecular Biology, University of Zielona Gora, Zielona Gora, Poland

autor

Sikorski A. F.

• Laboratory of Cytochemistry, Faculty of Biotechnology, University of Wroclaw, Poland

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