Comparison of the utility of the classic model (the Henderson-Hasselbach equation) and the Steward model (Strong Ion Approach) for the diagnostics of acid-base balance disorders in dogs with right sided heart failure

• Autorzy: Slawuta P. , Glinska-Suchocka K.
• Języki publikacji: EN

Abstrakty

EN

Classically, the acid-base balance (ABB) is described by the Henderson-Hasselbach equation, where the blood pH is a result of a metabolic components – the HCO₃⁻ concentration and a respiratory component – pCO₂. The Stewart model assumes that the proper understanding of the organisms ABB is based on an analysis of: pCO₂, Strong Ion difference (SID) – the difference strong cation and anion concentrations in the blood serum, and the Acid total (Atot) – the total concentration of nonvolatile weak acids. Right sided heart failure in dogs causes serious haemodynamic disorders in the form of peripheral stasis leading to formation of transudates in body cavities, which in turn causes ABB respiratory and metabolic disorders. The study was aimed at analysing the ABB parameters with the use of the classic method and the Stewart model in dogs with the right sided heart failure and a comparison of both methods for the purpose of their diagnostic and therapeutic utility. The study was conducted on 10 dogs with diagnosed right sided heart failure. Arterial and venous blood was drawn from the animals. Analysis of pH, pCO₂ and HCO₃⁻ was performed from samples of arterial blood. Concentrations of Na+, K+, Cl-, Pinorganic, albumins and lactate were determined from venous blood samples and values of Strong Ion difference of Na+, K+ and Cl- (SID₃), Strong Ion difference of Na+, K+, Cl- and lactate (SID4), Atot, Strong Ion difference effective (SIDe) and Strong Ion Gap (SIG₄) were calculated. The conclusions are as follows: 1) diagnosis of ABB disorders on the basis of the Stewart model showed metabolic alkalosis in all dogs examined, 2) in cases of circulatory system diseases, methodology based on the Stewart model should be applied for ABB disorder diagnosis, 3) if a diagnosis of ABB disorders is necessary, determination of pH, pCO₂ and HCO₃⁻ as well as concentrations of albumins and Pinorganic should be determined on a routine basis, 4) for ABB disorder diagnosis, the classic model should be used only when the concentrations of albumins and Pinorganic are normal.

Słowa kluczowe

EN

utility; classic model; Henderson-Hasselbach equation; Steward model; diagnostics; acid-base balance; disorder; dog; right-sided heart failure; animal disease

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2012
• Tom: 15
• Numer: 1
• Opis fizyczny: p.119-124,ref.

Twórcy

autor

Slawuta P.

• Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl.Grunwaldzki 47, 50-366 Wroclaw, Poland

autor

Glinska-Suchocka K.

Bibliografia

• Boyle M, Baldwin I (2002) Introduction to an alternate view of acid/base balance: the strong ion difference or Stewart approach. Aust Crit Care 15: 14-20.
• Constable PD (2000) Clinical assessment of acid-base status: comparison of the Henderson-Hasselbalch and strong ion approaches. Vet Clin Pathol 29: 115-128.
• Constable PD (2003) Hyperchloremic acidosis: the classic example of strong ion acidosis. Anesth Analg 96: 919-922
• Constable PD, Stampfli HR (2005) Experimental determination of net protein charge and A(tot) and K(a) of nonvolatile buffers in canine plasma. J Vet Intern Med 19: 507-514.
• Corey HE (2005) Bench-to -bedside review: Fundametal principles of acid-base physiology. Crit Care 9: 184-192.
• DiBartola SP (2006a) Introduction to acid – base disorders. In: DiBartola SP (ed) Fluid, electrolyte and acid base disorders in small animal practice. Saunders Elsevier, St Louis, pp 229-251.
• DiBartola SP (2006b) Metabolic acid – base disorders. In: DiBartola SP (ed) Fluid, electrolyte and acid base disorders in small animal practice. Saunders Elsevier, St Louis, pp 269-283.
• Elkhair NM, Siegling-Vlitakis C, Radtke E, Willing A, Hartmann H (2009) Age-dependent response of the acid-base parameters (Henderson-Hasselbalch, Stewart) in healthy calves with experimentally induced metabolic acidosis. Berl Munch Tierarztl Wochenschr 122: 63-69.
• Elkhair NM, Hartmann H (2010) Studies on acid-base status (Stewart’s model) of young camels (Camelus dromedarius) after acid-load with NH4Cl. Berl Munch Tierarztl Wochenschr 123: 153-159.
• Glińska K, Hałoń A, Pasławska U, Noszczyk-Nowak A, Nicpoń J, Rabczyński J (2006) Histopahological changes in the liver in right side heart failure in dogs. Med Weter 62: 1276-1280.
• Lambert C, Halpert JR, Rouleau J, Jutras L, Leroyer V, du Souich P (1991) Effect of congestive heart failure on the intrinisic metabolic capacity of the liver in the dog. Drug Metab Dispos 19: 985-989.
• McCullough SM, Constable PD (2003) Calculation of the total plasma concentration of nonvolatile weak acids and the effective dissociation constant of nonvolatile buffers in plasma for use in the strong ion approach to acid-base balance in cats. Am J Vet Res 64: 1047-1051.
• Morris CG, Low J (2008) Metabolic acidosis in the critically ill: part 1. Classification and pathophysiology. Anaesthesia 63: 294-301.
• Rehm M, Conzen PF, Peter K, Finsterer U (2004) The Stewart model. “Modern” approach to the interpretation of the acid-base metabolism. Anaesthesist 53: 347-357.
• Russell KE, Hansen BD, Stevens JB (1996) Strong ion difference approach to acid-base imbalances with clinical applications to dogs and cats. Vet Clin North Am Small Anim Pract 26: 1185-1201.
• Siegling-Vlitakis C, Kohn B, Kellermeier C, Schmitz R, Hartmann H (2007) Qualification of the Stewart variables for the assessment of the acid-base status in healthy dogs and dogs with different diseases. Berl Munch Tierarztl Wochenschr 120: 148-155.
• Sławuta P, Nicpoń J, Skrzypczak P (2010) Contemporary approach to acid-base balance and its disorders in dogs and cats Pol J Vet Sci 13: 561-567.
• Stewart PA (1978) Independent and dependent variables of acid – base control. Respir Physiol 33: 9-26.
• Stewart PA (1983) Modern quantitative acid-base chemistry. Can J Physiol Pharmacol 61: 1444-1461.
• Wall RE (2001) Respiratory acid-base disorders Vet Clin North Am Small Anim Pract 31: 1355-1367.
• Winnicka A (1997) Badanie biochemiczne krwi. In: Winnicka A (ed) Wartości referencyjne podstawowych badań laboratoryjnych w weterynarii. Wydawnictwo SGGW, Warszawa, pp 37, 38, 44, 49, 51, 58, 62, 65.
• Wooten EW (2004) Science review: quantitative acid-base physiology using the Stewart model. Crit Care 8: 448-452.