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2012 | 56 | 4 |

Tytuł artykułu

Influence of magnesium on the deposition of cadmium in rats

Autorzy

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Magnesium chloride was given via drinking water (500 mg Mg/L) to rats exposed intragastrically to cadmium (cadmium 109) at a dose corresponding to 10 mg/kg diet for 7, 14, 21, and 28 d. The results provided the evidence that magnesium decreased cadmium retention in the duodenum, kidneys, and liver after 7 d. Significant reduction in cadmium retention was also found on days 14 d and 21 in kidneys. No significant decreases in cadmium retention in the organs examined were noted after 28 d. The results suggest that beneficial action of magnesium on body cadmium accumulation ceased with time after the two metal administration.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

56

Numer

4

Opis fizyczny

p.591-594,ref.

Twórcy

autor
  • Laboratory of Radiological Protection and Isotopic Research, National Veterinary Research Institute. 24-100 Pulawy, Poland

Bibliografia

  • 1. Boujelben M., Ghorbel F., Vincent Ch., Makni-Ayadi F., Guermazi F., Croute F., El-Feki A.: Lipid peroxidationand HSP72/73 expression in rats following cadmium chloride administration: Interaction of magnesium supplementation. Exp Toxicol Pathol 2006, 57, 437-443.
  • 2. Brzóska M.M., Moniuszko-Jakoniuk J.: The influence of calcium content in diet on accumulation and toxicity of cadmium in the organism. Arch Toxicol 1998, 72, 63-73.
  • 3. Bulat Z.P., Djukic-Cosic D., Malicevic Z., Bulat P., Matovic V.: Zinc or magnesium supplementation modulates Cd intoxication in blood, kidney, spleen, and bone of rabbits. Biol Trace Elem Res 2008, 124, 110- 117.
  • 4. Djukic-Cosic D., Ninkovic M., Malicevic Z., Plamenac- Bulat Z., Matovic V.: Effect of supplemental magnesium in the kidney levels of cadmium. Zinc and copper of mice exposed to toxic level of cadmium. Biol Trace Elem Res 2006, 114, 281-292.
  • 5. Elsenhans B., Schumann K., Forth W.: Toxic metals: interactions with essential metals. In: Nutrition, toxicity, and cancer, edited by Rowlan I.R., Boca Raton. New York, 1991, pp. 223-258.
  • 6. Gaal K.K., Safar O., Gulyas L., Stadler P.: Magnesium in animals nutrition. J Am Coll Nutr 2004, 23, 754S-757S.
  • 7. Goyatain A., Quamme G.A.: Identification and characterization of ACDP2 (ancient conserved domain protein), a dicvalen metal transporter. Physiol Genomics 2005, 6, 48-66.
  • 8. Grosicki A., Kowalski B.: Absorption and distribution of cadmium in rats fed a copper enriched diet. Bull Vet Inst Pulawy 2001, 45, 333-340.
  • 9. Jarup L., Akesson A.: Current status of cadmium as an environmental health problem. Toxicol Appl Pharm 2008, 238, 201-208.
  • 10. Jihen E.H., Imed M., Fatima K., Abdelhamid K.: Protective effect of selenium and zinc on cadmium toxicity in the liver and kidney of the rat: histology and Cd accumulation. Food Chem Toxicol 2008, 46, 3522- 3527.
  • 11. Kabata-Pendias A., Mukherjee A.B.: Cadmium In: Trace elements in soil and human, edited by Springer-Verlag, Berlin Heidelberg, 2008, pp. 294-307.
  • 12. Kotyzova D., Cerna P., Leseticky L., Eybl V.: Trace elements status in selenium-deficient rats - interaction with cadmium. Biol Trace Elem Res 2010, 136, 287-293.
  • 13. Matovic V., Bulat Z.P., Djukic-Cosic D., Soldatovic D.: Antagonism between cadmium and magnesium: a possible role of magnesium in the therapy of cadmium intoxication. Magnesium Res 2010, 23, 19-26.
  • 14. Nordberg G.F., Nogawa K., Nordberg M., Friberg L.: Cadmium. In: Handbook on the toxicology of metals, edited by Nordberg G.F., Fowler G.F., Nordberg M., Friberg L., Amsterdam Elsevier, 2007. pp. 445-486.
  • 15. Park J.D., Cherrington N.J., Klaassen C.D.: Intestinal absorption of cadmium is associated with divalent metal transporter in rats. Toxicol Sci 2002, 68, 288-294.
  • 16. Reeves P.G., Chaney R.L.: Nutritional status affects the absorption and whole-body and organ retention of cadmium in rats fed rice-based diet. Environ Sci Technol 2002, 36, 2684-2692.
  • 17. Rogalska J., Pilat-Marcinkiewicz B., Brzózka M.M.: Protective effect of zinc against cadmium hepatotoxicity depends on this bioelement intake and level of cadmium exposure: A study in a rat model. Chem Biol Interact 2011, 193, 191-203.
  • 18. Swimanathan R.: Magnesium metabolism and its disorders. Clin Biochem Rev 2003, 24, 47-66.
  • 19. Van Barneveld A.A., Van den Hamer C.J.: Influence of Ca and Mg on the uptake and deposition of Pb and Cd in mice. Toxicol Appl Pharmacol 1985, 15, 1-10.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-cd19b0ad-bde3-46d2-89bc-a8c927bb14f0
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