Patterns of drug-resistant bacteria in a general hospital, China, 2011-2016

• Autorzy: Mao T. , Zhai H. , Duang G. , Yang H.
• Języki publikacji: EN

Abstrakty

EN

Drug-resistant bacteria has been a threat to public life and property. We described the trends and changes in antibiotic resistance of impor-tant pathogens in a general hospital in Zhengzhou, China from 2011 to 2016, to control antimicrobial-resistant bacteria in hospital and provide support to clinicians and decision-making departments.Five dominant bacteria were enrolled based on the data from the general hospital during 6 years. The results of antimicrobialsusceptibility testing were interpreted according to Clinical and Laboratory Standards Institute (CLSI). From 2011 to 2016, a total of 19,260 strains of bacteria were isolated, of which Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosaand Acinetobacter baumannii accounted for 51.98%. The resistance rate of K. pneumoniae and E. coli to carbapenem was less than 15%, but resistance of K. pneumoniae to carbapenems increased with time and resistance of E. coli to meropenem increased. The rate of extended-spectrum beta-lactamase (ESBL) production among K. pneumoniae and E. coli was decreasing. For most antibiotics, the resistance rate of ESBL-positive isolates was higher than that of ESBL-negative isolates, excluding carbapenems and cefoxitin. For S. aureus, the rate of methicillin-resistant S. aureus (MRSA) was stable. Resistance of S. aureus to mostly antibiotics decreased with time. Besides polymyxin B, P. aeruginosa and A. baumannii showed high resistance to other antibiotics. For A. baumannii, the resistance rate to mostly antibioticswas increasing. The bacteria showed high levels of resistance and multiple drug resistance. Continuous surveillance and optimizing the use of antibiotics are essential.

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2019
• Tom: 68
• Numer: 2
• Opis fizyczny: p.225-232,ref.

Twórcy

autor

Mao T.

• Department of Epidemiology, College of Public Health of Zhengzhou University, Zhengzhou, Henan, China

autor

Zhai H.

• Department of Epidemiology, College of Public Health of Zhengzhou University, Zhengzhou, Henan, China

autor

Duang G.

• Department of Epidemiology, College of Public Health of Zhengzhou University, Zhengzhou, Henan, China

autor

Yang H.

• Department of Epidemiology, College of Public Health of Zhengzhou University, Zhengzhou, Henan, China

Bibliografia

• Agodi A, Barchitta M, Quattrocchi A, Maugeri A, Aldisio E, Marchese AE, Mattaliano AR, Tsakris A. Antibiotic trends of Klebsiella pneumoniae and Acinetobacter baumannii resistance indicators in an intensive care unit of Southern Italy, 2008–2013. Antimicrob Resist Infect Control. 2015 Dec;4(1):43.doi:10.1186/s13756-015-0087-y Medline
• Blair JMA, Richmond GE, Piddock LJV. Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance. Future Microbiol. 2014 Oct;9(10):1165–1177.doi:10.2217/fmb.14.66 Medline
• Chung J, Bhat A, Kim C, Yong D, Ryu C. Combination therapy with polymyxin B and netropsin against clinical isolates of multidrug-resistant Acinetobacter baumannii. Sci. Rep.-UK. 2016;6:28168.CLSI. Performance Standards for Antimicrobial Susceptibility Test-ing. Wayne (USA): Clinical Laboratory Standards Institute; 2017.
• Hoffman SJ, Outterson K, Røttingen JA, Cars O, Clift C, Rizvi Z, Rotberg F, Tomson G, Zorzet A. An international legal framework to address antimicrobial resistance. Bull World Health Organ. 2015 Feb 01;93(2):66–66. doi:10.2471/BLT.15.152710 Medline
• Holbrook SYL, Garneau-Tsodikova S. Evaluation of aminoglycoside and carbapenem resistance in a collection of drug-resistant Pseudomonas aeruginosa clinical isolates. Microb Drug Resist. 2018 Sep;24(7):1020–1030. doi:10.1089/mdr.2017.0101 Medline
• Holden MTG, Feil EJ, Lindsay JA, Peacock SJ, Day NPJ, Enright MC, Foster TJ, Moore CE, Hurst L, Atkin R, et al.Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci USA. 2004 Jun 29;101(26):9786–9791.doi:10.1073/pnas.0402521101 Medline
• Hu FP, Guo Y, Zhu DM, Wang F, Jiang XF, Xu YC, Zhang XJ, Zhang CX, Ji P, Xie Y. Resistance trends among clinical isolates in China reported from CHINET surveillance of bacterial resistance, 2005–2014. Clin. Microbiol. Infec. 2016;22:S9–S14.
• Ito T, Katayama Y, Asada K, Mori N, Tsutsumimoto K, Tiensasitorn C, Hiramatsu K. Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus.Antimicrob Agents Chemother. 2001 May 01;45(5):1323–1336.doi:10.1128/AAC.45.5.1323-1336.2001 Medline
• Khan ER, Aung MS, Paul SK, Ahmed S, Haque N, Ahamed F, Sarkar SR, Roy S, Rahman MM, Mahmud MC, et al. Prevalence and molecular epidemiology of clinical isolates of Escherichia coliand Klebsiella pneumoniae harboring Extended-Spectrum Beta-Lactamase and carbapenemase genes in Bangladesh. Microb Drug Resist. 2018 Dec;24(10):1568–1579.doi:10.1089/mdr.2018.0063 Medline
• Lafaurie M, Porcher R, Donay JL, Touratier S, Molina JM. Reduction of fluoroquinolone use is associated with a decrease in methicillin-resistant Staphylococcus aureus and fluoroquinolone-resistant Pseudomonas aeruginosa isolation rates: a 10 year study.J Antimicrob Chemother. 2012 Apr 01;67(4):1010–1015.doi:10.1093/jac/dkr555 Medline
• Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, Doi Y, Tian G, Dong B, Huang X, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016 Feb;16(2):161–168.doi:10.1016/S1473-3099(15)00424-7 Medline
• Livermore DM. Fourteen years in resistance. Int J Antimicrob Agents. 2012 Apr;39(4):283–294.doi:10.1016/j.ijantimicag.2011.12.012 Medline
• Michael CA, Dominey-Howes D, Labbate M. The antimicrobial resistance crisis: causes, consequences, and management. Front Public Health. 2014 Sep 16;2:145.doi:10.3389/fpubh.2014.00145 Medline
• Olufunmiso O, Tolulope I, Roger C. Multidrug and vancomycin resistance among clinical isolates of Staphylococcus aureus from different teaching hospitals in Nigeria. Afr Health Sci. 2017 Sep 18;17(3):797–807. doi:10.4314/ahs.v17i3.23 Medline
• Panesso D, Planet PJ, Diaz L, Hugonnet JE, Tran TT, Narechania A, Munita JM, Rincon S, Carvajal LP, Reyes J,et al. Methicillin-Susceptible, Vancomycin-Resistant Staphylococcus aureus, Brazil. Emerg Infect Dis. 2015 Oct;21(10):1844–1848.doi:10.3201/eid2110.141914 Medline
• Pathak A, Chandran SP, Mahadik K, Macaden R, Lundborg CS.Frequency and factors associated with carriage of multi-drug resistant commensal Escherichia coliamong women attending antenatal clinics in Central India. BMC Infect Dis. 2013 Dec;13(1):199. doi:10.1186/1471-2334-13-199 Medline
• Peneş NO, Muntean AA, Moisoiu A, Muntean MM, Chirca A, Bogdan MA, Popa MI. An overview of resistance profiles ESKAPE pathogens from 2010–2015 in a tertiary respiratory center in Romania. Rom J Morphol Embryol. 2017;58(3):909–922. Medline
• Reale M, Strazzulla A, Quirino A, Rizzo C, Marano V, Postorino MC, Mazzitelli M, Greco G, Pisani V, Costa C, et al.Patterns of multi-drug resistant bacteria at first culture from patients admitted to a third level University hospital in Calabria from 2011 to 2014: implications for empirical therapy and infection control. Infez Med. 2017 Jun 1;25(2):98–107. Medline
• Rigatto MH, Vieira FJ, Antochevis LC, Behle TF, Lopes NT, Zavascki AP. Polymyxin B in Combination with Antimicrobials Lacking In Vitro Activity versus Polymyxin B in Monotherapy in Critically Ill Patients with Acinetobacter baumannii or Pseudomonas aeruginosa Infections. Antimicrob Agents Chemother. 2015 Oct; 59(10):6575–6580. doi:10.1128/AAC.00494-15 Medline
• Rossolini GM, Arena F, Pecile P, Pollini S. Update on the anti-biotic resistance crisis. Curr Opin Pharmacol. 2014 Oct;18:56–60. doi:10.1016/j.coph.2014.09.006 Medline
• Sugawara E, Nikaido H. OmpA is the principal nonspecific slow porin of Acinetobacter baumannii. J Bacteriol. 2012 Aug 01; 194(15):4089–4096. doi:10.1128/JB.00435-12 Medline
• Tan CK, Tang HJ, Lai CC, Chen YY, Chang PC, Liu WL. Correlation between antibiotic consumption and carbapenem-resistant Acinetobacter baumannii causing health care-associated infections at a hospital from 2005 to 2010. J Microbiol Immunol Infect. 2015 Oct;48(5):540–544. doi:10.1016/j.jmii.2014.02.004 Medline
• Tang X, Xiao M, Zhuo C, Xu Y, Zhong N. Multi-level analysis of bacteria isolated from inpatients in respiratory departments in China. J Thorac Dis. 2018 May;10(5):2666–2675.doi:10.21037/jtd.2018.04.46 Medline
• Ventola CL. The antibiotic resistance crisis: part 2: management strategies and new agents. P T. 2015 May;40(5):344–352. Medline
• Vincent JL. Nosocomial infections in adult intensive-care units. Lancet. 2003 Jun;361(9374):2068–2077.doi:10.1016/S0140-6736(03)13644-6 MedlineWalters MS, Eggers P, Albrecht V, Travis T, Lonsway D, Hovan G, Taylor D, Rasheed K, Limbago B, Kallen A. Vancomycin-Resistant Staphylococcus aureus – Delaware, 2015. MMWR Morb Mortal Wkly Rep. 2015 Sep 25;64(37):1056.doi:10.15585/mmwr.mm6437a6 Medline
• Wang S, Han LZ, Ni YX, Zhang YB, Wang Q, Shi DK, Li WH, Wang YC, Mi CR. Changes in antimicrobial susceptibility of commonly clinically significant isolates before and after the inter-ventions on surgical prophylactic antibiotics (SPAs) in Shanghai. Braz J Microbiol. 2018 Jul;49(3):552–558.doi:10.1016/j.bjm.2017.12.004 Medline
• Yang Q, Xu YC, Kiratisin P, Dowzicky MJ. Antimicrobial activity among gram-positive and gram-negative organisms collected from the Asia-Pacific region as part of the Tigecycline Evaluation and Surveillance Trial: comparison of 2015 results with previous years. Diagn Microbiol Infect Dis. 2017 Dec;89(4):314–323.doi:10.1016/j.diagmicrobio.2017.08.014 Medline
• Zgurskaya HI, López CA, Gnanakaran S. Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It. ACS Infect Dis. 2015 Nov 13;1(11):512–522.doi:10.1021/acsinfecdis.5b00097 Medline

Identyfikatory

DOI

10.33073/pjm-2019-024