Role of cholecystokinin in postprandial and vagally stimulated duodenal and gallbladder motility in dogs

• Autorzy: Thor P. , Laskiewicz J. , Maczka M. , Konturek S. J.
• Języki publikacji: EN

Abstrakty

EN

This study was designed to determine the role of cholecystokinin (CCK) in postprandial motility pattern of the duodenum and gallbladder (GB) in conscious dogs provided with chronic duodenal electrodes for recording of myoelectric activity and GB fistulas for measurement of intraluminal pressure and volume of GB and to calculate the GB motility index (MI) and GB emptying rate. During naturally occuring activity front (phase III MMC) in the duodenum there was significant increase in the MI of GB accompanied by about 20-30% reduction in the GB volume. These changes in duodenal and GB motility pattern could be duplicated by i. v. motilin. Feeding abolished the appearence of spontaneous activity front in the duodenum and greatly increased motility of GB while reducing its volume. Administration of CCK receptor antagonists in fed dogs failed to affect the motility changes induced by meal in the duodenum but abolished these of the GB. Vagal cholinergic stimulation with insulin, 2DG or urecholine caused similar effects to that induced by food i. e. increased duodenal spike activity, abolished phase III of the MMC, decreased GB volume and increased GB motility. Pretreatment with CCK antagonists did not affect significantly duodenal spike activity or GB motility but significantly increased the GB volume. Atropine 125 µg/kg) blocked almost completely spontaneous activity front in the duodenum and accompanying alterations in the motiliti and volume of GB. We conclude that CCK contributes to the MMC related alterations in the GB motor activity and is essential in cholinergic stimulation induced of the GB emtying but not in vagally induced duodenal and GB motility.

Słowa kluczowe

EN

gallbladder; motility; vagus stimulation; insulin; cholecystokinin; motor activity; duodenum; dog

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1991
• Tom: 42
• Numer: 4
• Opis fizyczny: p.381-388,fig.,ref.

Twórcy

autor

Thor P.

• Institute of Physiology, University Medical School, Grzegorzecka 16, 31-531 Krakow, Poland

autor

Laskiewicz J.

• Institute of Physiology, University Medical School, Grzegorzecka 16, 31-531 Krakow, Poland

autor

Maczka M.

• Institute of Physiology, University Medical School, Grzegorzecka 16, 31-531 Krakow, Poland

autor

Konturek S. J.

• Institute of Physiology, University Medical School, Grzegorzecka 16, 31-531 Krakow, Poland

Bibliografia

• 1. Ivy AC, Oldberg E. A hoimonal mechanism for gallbladder contractions and evacuation. Am J Physiol 1928; 86: 599-613.
• 2. Thor P, Laskiewicz J, Konturek P, Konturek SJ. Cholecystokinin in the regulation of intestinal motility and pancreatic secretion in dogs. Am J Physiol 1988; 255; G498-504.
• 3. Konturek SJ, Tasler J, Bilski J, De Jong AJ, Jansen JB, Lamers CB. Physiological role and localization of cholecystokinin release in.dogs. Am J Physiol 1986; 250: G 391-G395.
• 4. Mukhopadhyay AK, Thor PJ, Copeland EM, Johnson LR, Weisbrodt NW. Effect of cholecystokinin on myoelectric activity of small bowel of the dog. Am J Physiol 1977; 232: E44-47.
• 5. Wiener IK, Inoue CJ. Fagan P Thompson JC. Release of cholecystokinin in man; correlation of blood levels with gallbladder contractions. Ann Surg 1981; 194: 321-327.
• 6. Traynor OJ, Dozois RR, Di Magno EP. Canine interdigestive and postprandial gallbladder motility and emptying. Am J Physiol 1984; 256: G426-G432.
• 7. Fried GM, Ogden WD, Greeley Y, Thompson JC. Corelation of release and action of CCK in dogs befoie and afer vagotomy. Surgery St Louis 1983; 93: 786-791.
• 8. Bainbridge FA, Dale HM. The contractile mechanism of the gallbladder and its extrinsic nervous control. J Physiol 1906; 33: 138-139
• 9. Johnson FE, Boyden EA. The effect oi double vagotomy on the motor activity of the human gallbladder. Surgery St Louis 1952; 32: 591-601.
• 10. Parkin GJS, Smith RB, Johnston R. Gallbladder volume and contractility after truncal selective and highly selective vagotomy in man. Ann Surg 1973; 178: 581-586.
• 11. Amdrup BM, Griffith CA. The effects of vagotomy upon biliary function in dogs. J Surg Res 1970; 10 : 209-212.
• 12. Isaza JD, Jones T, Dragstedt LR, Woodward ER. The effect of vagotomy on motor function of the gallbladder. Surgery St Lozis 1971; 70: 616-621.
• 13. Niederau C, Karaus M. Effect of CCK recep ors blockade on fed and fasted small bowel intestinal motor activity. Gastroenterology 1989; 96: A366.
• 14. Suzuki T, Dodds WJ, Sarna SK et al. Control mechanisms of sphincter of Oddi contraction rate in the opossum. Am J Physiology 1988; 255: G619-626.
• 15. Debas HT, Yamagishi N. Evidence for a pyloro-cholecystic reflex for gallbladder contraction. Ann Surg 1979; 190: 170-175.
• 16. Itoh Z, Takahashi LW, Dodds WJ et al. Effect of proglumide on biliary tract contiactile activity in the opossum. Gastroenterology 1984; 86: 1274.