PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2011 | 71 | S |
Tytuł artykułu

Hippocampal interneuron types specifically related to complex behaviours

Autorzy
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The morphological, neurochemical and electrophysiological characterization of inhibitory, GABAergic cell types in the hippocampus allowed the introduction of a detailed functional classification. Several lines of evidence underlies a division of labor between major interneuron classes in cortical information processing. The latest results led to the hypothesis that specificity can go as far as activity patterns of individual cell types are directly related tto complex behaviours. The example used in this talk include basket cells; they control the ensemble activity and synchronization of principal neurons and are divided into two major types with different connectivities and functions: one characterized by the expression of the calcium-binding protein parvalbumin (PV) while the other contains the neuropeptide CCK. The electrically and synaptically coupled ensembles of PV-containing basket cells are indispensable components of the oscillating cortical hardware; they represent the rigid (nonplastic) precision clockwork without which no cortical operations are possible. The activity of a similar syncytium of CCK-containing basket cells is superimposed on the PV basket cell-entrained network, conveying the emotional and motivational effects carried by subcortical pathways (containing serotonin, for example). Actions of the CCK cell ensemble are highly modifiable also by local neuromodulators and retrograde signal molecules, which may allow further fine-tuning of principal cell cooperation. Impairment of this tuning system likely results in mood disorders such as anxiety. Endocannabinoid signaling plays a crucial role in regulating postsynaptic effects of the CCK cell ensemble (i.e., the fine-tuning device) and therefore is an ideal target for the pharmacotherapy of anxiety-like behaviors.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
71
Numer
S
Opis fizyczny
p.12
Twórcy
autor
  • Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
Bibliografia
Uwagi
Rekord w opracowaniu
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-c8ced036-482a-4de1-88a5-7f67fa3ae235
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.