Endothelial progenitor cells populate the stromal stem niche of tympanum

• Autorzy: Rusu M.C. , Manoiu V.S. , Popescu V.M. , Ciuluvica R.C.
• Języki publikacji: EN

Abstrakty

EN

The tympanic membrane (TM) integrity is of utmost importance for the sense of hearing. Therefore, the intrinsic potential of the TM to regenerate and repair deserves complete characterisation. Existing studies brought evidence on the epithelial stem niche of the TM. However, the stromal compartment was not evaluated for harbouring a distinctive stem, or progenitor, niche. We aimed doing this in transmission electron microscopy. We used TMs dissected out from 3 male Oryctolagus cuniculus rabbits. Evidence of stromal quiescent stem cells was gathered. Moreover, endothelial progenitor cells were found in the TM, being accurately identified by two specific ultrastructural markers of the endothelial lineage: the Weibel-Palade bodies and the stomatal diaphragms of the subplasmalemmal caveolae. The stromal stem niche of the TM appears to be a distinctive contributor during physiological and pathological processes of the TM, such as cholesteatoma formation, at least as a biological support for processes of vasculogenesis. However, further characterisation of the molecular pattern of the stromal stem niche of the TM is mandatory. (Folia Morphol 2017; 76, 4: 630–634)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2017
• Tom: 76
• Numer: 4
• Opis fizyczny: p.630-634,fig.

Twórcy

autor

Rusu M.C.

• Division of Anatomy, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
• MEDCENTER — Centre of Excellence in Laboratory Medicine and Pathology, Bucharest, Romania

autor

Manoiu V.S.

• Department of Cellular and Molecular Biology, National Institute of Research and Development for Biological Sciences, Bucharest, Romania

autor

Popescu V.M.

• Department of Cellular and Molecular Biology, National Institute of Research and Development for Biological Sciences, Bucharest, Romania

autor

Ciuluvica R.C.

• Division of Anatomy, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

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Identyfikatory

DOI

10.5603/FM.a2017.0038