Association of MC4R and LEPR loci with reproductive performance and milk composition of sows

• Autorzy: Szyndler-Nedza M. , Ropka-Molik K.
• Języki publikacji: EN

Abstrakty

EN

Porcine MC4R and LEPR gene polymorphisms have been implicated in traits associated with feed intake and carcass fatness. These genes could also indirectly regulate reproductive processes. The objective of this study was to determine the MC4R and LEPR effects on basic components of colostrum and milk from sows on their reproductive performance. The experiment was performer on 230 sows of breeds used in the breeding program as a maternal line: Polish Large White (PLW)and Polish Landrace (PL). The animals were maintained under the same feeding and housing conditions, according to the test station procedure and they were adapted for use as lactating sows.Colostrum and milk of sows were collected at 1, 7, 14 and 21 days of lactation to assay solids, total protein, fat and lactose. Data on piglet rearing performance were collected at 1, 7 and 21 days of lactation. The present study showed that MC4R and LEPR genes affected carcass fat deposition In sows and influenced production of nutrient-rich milk. Sows of the MC4RAA genotype, as well as sows of the LEPRBB genotype, characterized by a greater backfat thickness, produced colostrum with a lower content of fat, protein and solids. In addition, the fact that the investigated polymorphisms have no effect on piglet rearing results suggests that these markers could be used in selecting pigs for decreased backfat thickness, without fear of reducing the quality of milk and thereby piglet Reading performance.

• Wydawca: -
• Czasopismo: Animal Science Papers and Reports
• Rocznik: 2015
• Tom: 33
• Numer: 3
• Opis fizyczny: p.267-276,ref.

Twórcy

autor

Szyndler-Nedza M.

• Department of Animal Genetics and Breeding, National Research Institute of Animal Production, Krakowska 1, 32-083 Balice, Poland

autor

Ropka-Molik K.

• Laboratory of Genomics, National Research Institute of Animal Production, Krakowska 1, 32-083 Balice, Poland

Bibliografia

• ALSTON-MILLS B., IVERSON S.J., THOMPSON M.P., 2000 – A comparison of the composition of milks from Meishan and crossbred pigs. Livestock Production Science 63, 85-91.
• ARIZA-NIETO C., BANDRICK M., BAIDOO S.K., ANIL L., MOLITOR T.W., HATHAWAY M.R., 2011 – Effect of dietary supplementation of oregano essential oils to sows on colostrum and milk composition, growth pattern and immune status of suckling pigs. Journal of Animal Science 89, 1079-1089.
• BABICZ M., CICHOCKI R., KASPRZAK K., KROPIWIEC K., SZUBA K., 2011 – Analysis of relationship between sows colostrum and milk somatic cell count and reproductive performance traits. Annales Universitatis Mariae Curie-Skłodowska, Sectio EE 3, 1-13.
• BABICZ M., SKRZYPCZAK E., REJDUCH B., KOZUBSKA-SOBOCIŃSKA A., CHMIELOWIEC-KORZENIOWSKA A., KASPRZAK K., 2012 – Effect of thermal stress on reproductive performance parameters of sows with defined genotype at the RYR1 locus. Annals of Animal Science 12, 323-333.
• BANOS G., WOOLLIAMS J.A., WOODWARD B.W., FORBES A.B., COFFEY M.P., 2008 –Impact of single nucleotide polymorphisms in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows. Journal of Dairy Science 91, 3190-3200.
• BARB C.R., HAUSMAN G.J., CZAJA K., 2005 – Leptin: a metabolic signal affecting central regulation of reproduction in the pig. Domestic Animal Endocrinology 29, 186-192.
• BARŁOWSKA J., LITWIŃCZUK Z., FLOREK M., KĘDZIERSKA-MATYSEK M., 2007 – Field and composition of goat milk from 4 Polish breeds differing in αs1-casein genotype. Medycyna Weterynaryjna 63, 1600-1603.
• BEYER M., JENTSCH W., KUHLA S., WITTENBURG H., KREIENBRING F., SCHOLZE H., RUDOLPH P.E., METGES C.C., 2007 – Effects of dietary energy intake during gestation and lactation on milk yield and composition of first, second and fourth parity sows. Archives of Animal Nutrition 61, 452-468.
• BEYGA K., REKIEL A., 2009 – Effect of the backfat thickness of sows in late pregnancy on the composition of colostrum and milk. Archiv Tierzucht 52, 593-602.
• BURGOS C., CARRODEGUAS J.A., MORENO C., ALTARRIBA J., TARRAFETA L.,BARCELONA J.A., LÓPEZ-BUESA P., 2006 – Allelic incidence in several pig breeds of a missense variant of pig melanocortin-4 receptor (MC4R) gene associated with carcass and productive traits; its relation to IGF2 genotype. Meat Science 73, 144-150.
• GALVE A., BURGOS C., SILIÓ L., VARONA L., RODRIGUEZ C., OVILIO C., LÓPEZ-BUESA P., 2012 – The effects of leptin receptor (LEPR) and melanocortin-4 receptor (MC4R) polymorphisms on fat distribution and fat composition in a Duroc x Landrace/ Large White cross. Livestock Science 145, 145-152.
• GOURDINE J.L., BIDANEL J.P., NOBLET J., RENAUDEAU D., 2006 - Effects of breed and season on performance of lactating sows in a tropical humid climate. Journal of Animal Science 84, 360-369.
• HAUSMAN G.J., BARB C.R., 2010 – Adipose tissue and the reproductive axis: biological aspects.Endocrine Development 19, 31-44.
• KIM K.S., LEE J.J., SHIN H.Y., CHOI B.H., LEE C.K., KIM J.J., CHO B.W., KIM T.H., 2006 – Association of melanocortin 4 receptor (MC4R) and high mobility group AT-hook 1 (HMGA1) polymorphisms with pig growth and fat deposition traits. Animal Genetics 37, 419-421.
• LI X., KIM S.W., CHOI J.S., LEE Y.M., LEE C.K., CHOI B.H., KIM T.H., CHOI Y.I., KIM J.J., KIM K.S., 2010 – Investigation of porcine FABP3 and LEPR gene polymorphisms and mRNA expression for variation in intramuscular fat content. Molecular Biology Reports 37, 8, 3931-3939.
• MEIDTNER K., WERMTER A.K., HINNEY A., REMSCHMIDT H., HEBEBRAND J., FRIES R., 2006 – Association of the melanocortin 4 receptor with feed intake and daily gain in F2 Mangalitsa x Piétrain pigs. Animal Genetics 37, 245-247.
• ÓVILO C., OLIVER A., NOGUERA J.L., CLOP A., BARRAGÁN C., VARONA L., RODRIGUEZ C., TORO M., SÁNCHEZ A., PÉREZ-ENCISO M., SILIÓ L., 2002 – Test for positional candidate genes for body composition on pig chromosome 6. Genetics Selection Evolution 34, 465-79.
• PIÓRKOWSKA K., TYRA M., ROGOZ M., ROPKA-MOLIK K., OCZKOWICZ M., RÓŻYCKI M., 2010 – Association of the melanocortin-4 receptor (MC4R) with feed intake, growth, fatness and carcass composition in pigs raised in Poland. Meat Science 85, 297-301.
• PIERZCHAŁA M., PAREEK C.S., URBAŃSKI P., GOŁUCH D., KAMYCZEK M., RÓŻYCKI M., SMOCZYNSKI R., HORBAŃCZUK J.O., KURYŁ J., 2012 – Study of the differential transcription in liver of growth hormone receptor (GHR), insulin-like growth factors (IGF1, IGF2) and insulinlike growth factor receptor (IGF1R) genes at different postnatal developmental ages in pig breeds.Molecular Biology Reports 39, 3055-3066.
• REVELL D.K., WILLIAMS I.H., MULLAN B.P., RANFORD J.L., SMITS R.J., 1998 – Body composition at farrowing and nutrition during lactation affect the performance of primiparous sows:II. Milk composition, milk yield and pig growth. Journal of Animal Science 76, 1738-43.
• SCHMIDELY P.H., MESCHY F., TESSIER J., SAUVANT D., 2002 – Lactation response and nitrogen, calcium, and phosphorus utilization of dairy goats differing by the genotype for αs1-casein in milk, and fed diets varying in crude protein concentration. Journal of Dairy Science 85, 2299-2307.
• SKRZYPCZAK E., BABICZ M., SZULC K., WALENDOWSKA A., PANEK A., 2012 – Impact of sow milk protein polymorphism on piglet rearing. Annals of Animal Science 12, 335-347.
• STACHOWIAK M., SZYDŁOWSKI M., OBARZANEK-FOJT M., ŚWITOŃSKI M., 2006 – An effect of a missense mutation in the porcine melanocortin-4 receptor (MC4R) gene on production traits in Polish pig breeds is doubtful. Animal Genetics 37, 55–57.
• STRATIL A., KOPECNY M., MOSER G., SCHROFFEL J., CEPICA S., 1998 – HpaII and RsaI PCRRFLPs within an intron of the porcine leptin receptor gene (LEPR) and its linkage mapping.Animal Genetics 29, 398-413.
• SUCHOCKI T., KOMISAREK J., SZYDA J., 2010 – Testing candidate gene effects on milk production traits in dairy cattle under various parameterizations and modes of inheritance. Journal of Dairy Science 93, 2703-2717.
• SUN C., WANG L., JIANG D.F., ZHANG B., 2009 – Missense mutations in exon 2 of the porcie leptin receptor gene and their associations with litter size and body weight. Czech Journal of Animal Science 54, 210-216.
• SZULC K., KNECHT D., JANKOWSKA-MAKOSA A., SKRZYPCZAK E., NOWACZEWSKI S.,2013 - The influence of fattening and slaughter traits on reproduction in Polish Large White sows.Italian Journal of Animal Science 12, 16-20.
• SZYNDLER-NĘDZA M., RÓŻYCKI M., ECKERT R., MUCHA A., KOSKA M., SZULC T., 2013a – Relationships between chemical composition of colostrum and milk and rearing performance of piglets during a 21 day lactation. Annals of Animal Science 4, 771-781.
• SZYNDLER-NĘDZA M., TYRA M., ROPKA-MOLIK K., PIÓRKOWSKA K., MUCHA A.,RÓŻYCKI M., KOSKA M., SZULC K., 2013b – Association between LEPR and MC4R genes polymorphism and composition of milk from sows of dam line. Molecular Biology Reports 40,4339-4347.
• TUMMARUK P., TANTASUPARUK W., TECHAKUMPHU M., KUNAVONGKRIT A., 2004 – Effect of season and outdoor climate on litter size at birth in purebred landrace and Yorkshire sows in Thailand. Journal of Veterinary Medical Science 66, 477-482.
• TYRA M., ROPKA-MOLIK K., 2011 – Effect of the FABP3 and LEPR gene polymorphisms and expression levels on intramuscular fat (IMF) content and fat cover degree in pigs. Livestock Science 142, 114-120.
• VALROS A., 2003 – Behaviour and physiology of lactating sows – associations with piglet performance and sow postweaning reproductive success. PhD thesis, Helsinki University, Finland. http://ethesis.helsinki.fi/julkaisut/ela/kliin/vk/valros/behaviou.pdf
• VAN DEN MAAGDENBERG K., STINCKENS A., CLAEYS E., SEYNAEVE M., CLINQUART A., GEORGES M., BUYS N., DE SMET S., 2007 – The Asp298Asn missense mutation in the porcine melanocortin-4 receptor (MC4R) gene can be used to affect growth and carcass traits without an effect on meat quality. Animal 1, 1089-1098.
• WANG W., HUE W., JIN B., ZHANG X., MA F., XU X., 2013 – Candidate gene expression affects intramuscular fat content and fatty acid composition in pigs. Journal of Applied Genetics 5, 113-118.
• Zhang C.Y., Wang Z., Bruce H.L., Janz J., Goddard E., Moore S., Plastow G.S.,2014 – Associations between single nucleotide polymorphisms in 33 candidate genes and meat quality traits in commercial pigs. Animal Genetics 45, 508-516.