The patch-clamp studies on the influence of selected polycyclic compounds on the activity of Kv1.3 channels in normal and cancer cells

• Autorzy: Teisseyre A. , Gasiorowska J. , Michalak K.
• Języki publikacji: EN

Abstrakty

EN

The influence of selected heterocyclic compounds on the activity of voltage-gated potassium channels Kv1.3 have been studied by the whole-cell patch-clamp technique. Studies were performed on the channels in the model system- human T lymphocytes isolated from peripheral blood of healthy donors – and in cancer cell line Jurkat T. The studied compounds were flavonoids, chalcones, substituted stilbenes and their natural and synthetic derivatives. This presentation summarizes results of the recent studies. It is shown that some of the studied compounds are inhibitors of Kv1.3 channels in the model system and in cancer cells. These compounds may be applied in the future to support therapy of some tumor diseases characterised by an overexpression of Kv1.3 channels.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.335

Twórcy

autor

Teisseyre A.

• Department of Biophysics, Wrocław Medical University, Wrocław, Poland

autor

Gasiorowska J.

• Department of Biophysics, Wrocław Medical University, Wrocław, Poland

autor

Michalak K.

• Department of Biophysics, Wrocław Medical University, Wrocław, Poland