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2011 | 71 | S |
Tytuł artykułu

The FORMIN 2 protein is required for the remodeling of consolidated memories

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The brain has a remarkable capacity to undergo plasticity changes that are believed to underlie the acquisition, consolidation and maintenance of memory traces. To identify the molecular and cellular substrates of cognitive function is a major aim of modern neuroscience. A critical mechanism that has been implicated with neuronal plasticity is the regulation of the actin cytoskeleton. Thus, we study the role of FORMIN 2 (FMN2), a protein that regulates actin dynamics, in the adult brain of mice. Fmn2-/- mice can normally form hippocampus-dependent associative and spatial memories but display a severe failure in adapting a once acquired memory. Thus, Fmn2-/- mice show dramatic impairments in reversal learning paradigms. On the molecular and cellular levels this phenotype is explained by deregulated actin dynamics in the hippocampal striatum lucidum linked to a reduced number of synaptic vesicles per active zone and led to specific changes in the physiology of mossy fiber-CA3 synapses. Our data indicates that FMN2 at the mossy fiber-CA3 synapse is required for the fine-tuning of hippocampal memory traces.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
71
Numer
S
Opis fizyczny
p.24
Twórcy
  • Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Goettingen, Germany
autor
  • CNRS UMR 5091, Institut Francois Magendie, Universite Bordeaux 2, Bordeaux, France
autor
  • CNRS UMR 5091, Institut Francois Magendie, Universite Bordeaux 2, Bordeaux, France
autor
  • Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Goettingen, Germany
autor
  • Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Goettingen, Germany
autor
  • STED Microscopy of Synaptic Function, European Neuroscience Institute, Goettingen, Germany
autor
  • CNRS UMR 5091, Institut Francois Magendie, Universite Bordeaux 2, Bordeaux, France
autor
  • Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Goettingen, Germany
Bibliografia
Uwagi
Rekord w opracowaniu
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-c36ef96a-5067-471d-a9f4-5a29f3457d6c
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