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2009 | 69 | 3 |
Tytuł artykułu

Cell-type specific regulation of morphine-and glucocorticoid induced genes

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Single morphine administration to mice leads to changes in the expression of numerous genes in mouse striatum. Among them are genes regulated by the glucocorticoid receptor activation, like Sgk1, Gilz and Plzf [Korostynski et al. (2007) Genome Biol]. Analysis of their expression patterns with the use of in situ hybridization revealed their different regional distribution throughout the brain. To verify the cellular specifi city of expression, the double immunohistochemical stainings were performed with antibodies directed against investigated proteins and cellular markers (NeuN, GFAP, CC1, OX42). The results show that certain morphine- and GR-induced proteins are expressed in neurons, whereas others in glial cells. Hence, their regulation depends on the cell-type specifi c context.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.340
Twórcy
autor
  • Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
autor
  • Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
autor
  • Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
autor
  • Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
autor
  • Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
  • Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
Bibliografia
Typ dokumentu
Bibliografia
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Identyfikator YADDA
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