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2009 | 69 | 3 |
Tytuł artykułu

Electrical stimulation of the medial septal nucleus increases cytotoxic activity of NK cells in the spleen and peripheral blood in rats

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The medial septal nucleus (MS) is a forebrain limbic structure involved in learning and memory mechanisms. In previous study we found that electrolytic lesion of the medial septal nucleus caused depression of the peripheral blood natural killer cell cytotoxicity (NKCC) and the leukocyte number. In the sham operated group mere insertion of electrodes into the MS evoked transient NKCC enhancement, probably resulting from mechanical MS stimulation. To check this effect in the present study, we evaluated both spleen and blood NKCC (51Cr-release assay) and large granular lymphocytes (LGL) number (a morphological method) after chronic electrical stimulation (constant current 0.1 ms duration cathodal pulses delivered at a frequency of 50 Hz during 30-min daily session for 14 consecutive days) of MS in conscious, freely moving rats (n=12). Additionally, peripheral blood leukocyte, lymphocyte and neutrophile number was mesaured. Chronic MS stimulation caused signifi cant blood NKCC augmentation and LGL number (25.86 ± 9.31% vs. 15.75 ± 4.75%, P<0.01) in comparison to the sham group (n=13). No signifi cant effect was found in the spleen (27.14 ± 9.99% vs. 28.58 ± 8.04%). A week after termination of the stimulation procedure all measured parameters returned to the baseline. The results obtained indicate that such limbic structure as medial septum enhances antitumor and antiviral function and number of NK cells.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.363
Twórcy
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
Bibliografia
Typ dokumentu
Bibliografia
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Identyfikator YADDA
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