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2012 | 19 | 2 |

Tytuł artykułu

The influence of age on a clinical presentation of Toxocara spp. infection in children

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Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Toxocariasis is a helminthozoonosis due to the infestation of humans by roundworms, Toxocara spp. Actual informations indicate it the most common worm infection in many countries, typically connected with rural areas. The authors analyzed the documentation of 84 children with positive serology to this worm. An individual record was made and following data were restricted: anamnesis data, clinical symptoms, epidemiological data, eosinophils number, level of immunoglobulins G and E. The highest Toxocara spp. seropositivity frequency was found in the schoolchildren aged 7-10. The most frequent clinical findings in children infected Toxocara spp. were lymphadenopathy, hepatomegaly, arthralgia and arthritis. 15.5% of seropositive patients presented non-specific symptoms originating from the central nervous system: headaches, sleep and behavioural disorders, and hyperactivity. The mean eosinophilia in the peripheral blood was detected in the youngest children: 4,023 cell/μl, which is 15.55 times more than the limit value. Hyperimmunoglobulinemia E was detected in all age groups, and the youngest children presented a serum concentration of IgE that was 16.47 times higher than the limit value. Conclusions: 1. Toxocara spp. infection is detected in children at every age, but the most specific age group are schoolchildren, representing 38% of positive individuals. 2. The clinical spectrum of toxocariasis reflects various manifestations depending on the internal organs infected by the migrating worms and the intensity of infection. 3. Eosinophilia seems to be a good marker of infection in young children who have a more symptomatic course of the disease. 4. Hyperimmunoglobulinemia IgE can be the important element which distinguishes between current and past Toxocara infection, but its meaning is not connected with the age of infected children

Słowa kluczowe

Wydawca

-

Rocznik

Tom

19

Numer

2

Opis fizyczny

p.233-236,ref.

Twórcy

  • Department of Infectious Diseases and Child Neurology, K.Marcinkowski University of Medical Sciences, Poznań, Poland
autor
  • Department of Infectious Diseases and Child Neurology, K.Marcinkowski University of Medical Sciences, Poznań, Poland
  • Department of Infectious Diseases and Child Neurology, K.Marcinkowski University of Medical Sciences, Poznań, Poland; President Stanislaw Wojciechowski Higher Vocational State School, Kalisz, Poland
autor
  • Department of Infectious Diseases and Child Neurology, K.Marcinkowski University of Medical Sciences, Poznań, Poland
autor
  • Department of Infectious Diseases and Child Neurology, K.Marcinkowski University of Medical Sciences, Poznań, Poland
autor
  • Chair of Informatics and Statistics, University of Medical Sciences, Poznań, Poland

Bibliografia

  • 1. Espinoza YA, Huapaya PH, Roldani WH, Jimenezi S, Arce Z, Lopez E. Clinical and serological evidence of Toxocara infection inschool children from Morrope district, Lambayeque, Peru. Rev InstMed Trop S. Paulo. 2008; 50(2): 101-105.
  • 2. Hotez PJ, Wilkins PP. Toxocariasis: America’s Most Common Neglected Infection of Poverty and a Helminthiasis of Global Importance? PLoSNegl Trop Dis. 2009; 3(3): e400. doi:10.1371/journal.pntd.0000400
  • 3. Dispomier D. Toxocariasis: Clinical Aspects, Epidemiology, Medical Ecology, and Molecular Aspects Clin Microbiol. Rev. 2003; 16(2): 265-2723.
  • 4. Paul M., Stefaniak J, Twardosz-Pawlik H, Pecold K. The co-occurrence of Toxocara ocular and visceral larva migrans syndrome: a case series. Cases J. 2009; 2: 6881-6888.
  • 5. Cox DM, Holland CV. The relationship between numbers of larvae recovered from the brain of Toxocara canis-infected mice and socialbehavior and anxiety in the host. Parasitol. 1998; 116(6): 579-594.
  • 6. Pawłowski Z. Toxocariasis in humans. Clinical expression and treatment dilemma. J Helminth. 2001; 75(4): 299-305.
  • 7. Magnaval J-F, Glickman LT, Dorchies P, Morassin B. Highlights of human toxocariasis. Korean J Parasitol. 2001; 39(1): 1-11.
  • 8. Krawczyński M. Okresy rozwoju ontogenetycznego człowieka. In: Propedeutyka pediatrii. (Ed. M.Krawczynski. 1st ed. ) PZWL 2003.p. 34-35.
  • 9. Perlingiero JG, Gyorgy P. Chronic eosinophilia. Report of a case with necrosis of the liver, pulmonary infiltrations, anemia and ascarisinfestation. Am J Dis Child. 1947; 73(1): 34.
  • 10. Żarnowska-Prymek H. Enhancement of laboratory diagnosis specificity in human toxocariasis. Wiad Parazytol. 2001; 47: 489-96.
  • 11. Aguiar-Santos AM, Andrade LD, Medeiros Z, Chieffi PP, Lescano SZ, Perez EP. Human toxocariasis: Frequency of anti -Toxocara antibodiesin children and adolescents from an outpatient clinic for lymphaticfilariasis in Recife, Northeast Brazil Rev. Inst. Med. Trop. S. Paulo2004; 46(2): 81-85.
  • 12. Rayes AA, Lambertucci JR. Human toxocariasis as a possible cause of eosinophilic arthritis. Rheumatology 2001; 40(1): 109-110.
  • 13. Kwon N-H, Oh M-J, Lee S-P, Lee B-J, Choi D-C. The prevalence and diagnostic value of toxocariasis in unknown eosinophilia. Ann Hem.2006; 85(4): 233-238.
  • 14. Martín UO, Machuca PB, Demonte MA, Contini L. Analysis of children with a presumptive diagnosis of toxocariasis in Santa Fe, Argentina. Medicina (B Aires) 2008; 68(5): 353-357.
  • 15. Turner KJ, Feddema L, Quinn EH. Non-specific potentiation of IgE by parasitic infections in man. Int Arch Allergy Appl Immunol. 1979;58(2): 232.
  • 16. Niedworok M, Sordyl B, Borecka A, Gawor J, Małecka-Panas E. Estimation of eosinophilia, immunoglobulin E and eosinophiliccationic protein concentration during the treatment of toxocariasis.Wiad Parazytol. 2008; 54: 225-230.
  • 17. Carvalho EA, Rocha RL Toxocariasis: visceral larva migrans in children. J Pediatr. (Rio J) 2001; 87(2): 100-110.

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