PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2011 | 71 | S |
Tytuł artykułu

Calcium signaling networks in neural progenitor cells critically control cell division

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The complex and diverse cell signaling cascades underlying neural progenitor cell division and differentiation remain poorly understood. Here we demonstrate that neural progenitor cells are forming calcium (Ca2+) networks in the embryonic brain that critically control cell division. This was observed in both BrdUpulsed animals and mouse embryonic stem (ES) cell-derived neural progenitors. The intracellular Ca2+ signal cascade is driven by electrical activity and influx of Ca2+-ions from the extracellular space. Mathematical cross-correlation analysis reveals more developed networks and stronger synchronicity of spontaneous Ca2+ activity in differentiated ES cells as compared to undifferentiated cells. The signaling mechanisms were independent of synaptic transmission and indicated that gap junctions where playing a major role in this signaling event. In summary, our results suggest a novel function for Ca2+ signaling networks in regulating cell division of neural progenitor cells.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
71
Numer
S
Opis fizyczny
p.26
Twórcy
autor
  • Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockolhm, Sweden
autor
  • Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockolhm, Sweden
autor
  • Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockolhm, Sweden
Bibliografia
Uwagi
Rekord w opracowaniu
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-bdd969a8-2e07-4380-b671-0f95fc89d518
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.