Platelet and intestinal 5-HT2A receptor mRNA in autistic spectrum disorders - results of a pilot study

• Autorzy: Kazek B. , Huzarska M. , Grzybowska-Chlebowczyk U. , Kajor M. , Ciupinska-Kajor M. , Wos H. , Marszal E.
• Języki publikacji: EN

Abstrakty

EN

The etiology and pathogenesis of autistic spectrum disorders (ASD) are still unknown. Platelet hyperserotonemia has been detected in 25-60% of autistic children. Higher incidence of gastrointestinal problems in people with autism is observed. The aim was compare the expression of platelet 5-HT2Ar mRNA in autistic and non autistic groups. In a subgroup of patients with gastrointestinal problems an upper gastrointestinal tract endoscopy was performed and additionally the expression of 5-HT2A receptor mRNA in the duodenum was assessed. The examination was conducted in 79 children - 51 with ASD and 28 without autistic traits. Statistically significant differences between the study and control groups were proven in gastrointestinal problems. The analyses reveal a significantly higher level of 5-HT2Ar mRNA in platelets of the study group patients, which could suggest serotonin system dysregulation.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2010
• Tom: 70
• Numer: 2
• Opis fizyczny: p.232-238,ref.

Twórcy

autor

Kazek B.

• Department of Child Neurology, Silesian Medical University, Katowice, Poland

autor

Huzarska M.

• Department of Clinical Pharmacology, Silesian Medical University, Katowice, Poland

autor

Grzybowska-Chlebowczyk U.

• Department of Pediatrics, Silesian Medical University, Katowice, Poland

autor

Kajor M.

• Department of Patomorphology, Silesian Medical University, Katowice, Poland

autor

Ciupinska-Kajor M.

• Department of Patomorphology, Silesian Medical University, Katowice, Poland

autor

Wos H.

• Department of Pediatrics, Silesian Medical University, Katowice, Poland

autor

Marszal E.

• Department of Child Neurology, Silesian Medical University, Katowice, Poland

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