Evaluation of the immune response of male and female rats vaccinated with cDNA encoding a cysteine proteinase of Fasciola hepatica (FhPcW1)

• Autorzy: Wesolowska A. , Norbury L. J. , Januszkiewicz K. , Jedlina L. , Jaros S. , Zawistowska-Deniziak A. , Zygner W. , Wedrychowicz H.
• Języki publikacji: EN

Abstrakty

EN

Not only do males and females of many species vary in their responses to certain parasitic infections, but also to treatments such as vaccines. However, there are very few studies investigating differences among sexes following vaccination and infection. Here we demonstrate that female Sprague-Dawley rats vaccinated with cDNA encoding a recently discovered cysteine proteinase of Fasciola hepatica (FhPcW1) develop considerably lower liver fluke burdens after F. hepatica infection than their male counterparts. This is accompanied by differences in the course of their immune responses which involve different eosinophil and monocyte responses throughout the study as well as humoral responses. It is evident that host gender influences the outcome of parasitic infections after vaccination and research on both sexes should be considered when developing new treatments against parasites.

Słowa kluczowe

EN

Fasciola hepatica; infection; sex difference; DNA vaccination; immunology; cysteine proteinase; immune response; rat; parasitic infection; liver fluke

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 2013
• Tom: 58
• Numer: 2
• Opis fizyczny: p.198-206,fig.,ref.

Twórcy

autor

Wesolowska A.

• Department of Molecular Biology, Laboratory of Molecular Parasitology, W. Stefanski Institute of Parasitology, Polish Academy of Sciences, 51/55 Twarda St., 00-818 Warsaw, Poland

autor

Norbury L. J.

• Department of Molecular Biology, Laboratory of Molecular Parasitology, W. Stefanski Institute of Parasitology, Polish Academy of Sciences, 51/55 Twarda St., 00-818 Warsaw, Poland

autor

Januszkiewicz K.

• Department of Molecular Biology, Laboratory of Molecular Parasitology, W. Stefanski Institute of Parasitology, Polish Academy of Sciences, 51/55 Twarda St., 00-818 Warsaw, Poland

autor

Jedlina L.

• Department of Molecular Biology, Laboratory of Molecular Parasitology, W. Stefanski Institute of Parasitology, Polish Academy of Sciences, 51/55 Twarda St., 00-818 Warsaw, Poland

autor

Jaros S.

• Department of Molecular Biology, Laboratory of Molecular Parasitology, W. Stefanski Institute of Parasitology, Polish Academy of Sciences, 51/55 Twarda St., 00-818 Warsaw, Poland

autor

Zawistowska-Deniziak A.

• Department of Molecular Biology, Laboratory of Molecular Parasitology, W. Stefanski Institute of Parasitology, Polish Academy of Sciences, 51/55 Twarda St., 00-818 Warsaw, Poland

autor

Zygner W.

• Division of Parasitology, Department of Preclinical Sciences, Warsaw University of Life Sciences, 8 Ciszewskiego St., 02-786 Warsaw, Poland

autor

Wedrychowicz H.

• Division of Parasitology, Department of Preclinical Sciences, Warsaw University of Life Sciences, 8 Ciszewskiego St., 02-786 Warsaw, Poland

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