PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2017 | 77 | Suppl.1 |
Tytuł artykułu

Functional interaction of excitatory foci and their complexes in the cerebral cortex

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
INTRODUCTION: Identification of the interaction between excitatory foci and their complexes in the cortex is important for understanding functional organization of the regions they arise from and help learn the pathophysiological mechanisms of various CNS pathologies development. AIM(S): We aimed to identify the types and mechanisms of interactions between excitatory foci with variable intensity and their complexes in the neocortex. METHOD(S): We used adult male cats and rats for applications of strychnine, penicillin, and acetylcholine with proserin to produce excitatory foci. In this experiment, we used different drug concentrations and application zones in the neocortex. RESULTS: We established two main types of interactions: the determinant and the dominant. A focus of more powerful excitation may enhance and synchronize the activity in the weaker foci, integrate them in a single functional complex and define the pattern of its activity (determinant relations). Phenobarbital or surgical excision of the neocortical region with hyperactive foci can suppress determinant foci and destroy the complex. The hyperactive focus may also suppress the activity of previously created foci (dominant relationships). We observed the latter form of interaction in either transitional stage during complex formation or it had an independent meaning. The interaction between foci did not depend on their neurochemical background and localization in the cortex. In cortex isolé and preparations with mesencephalic sections of the stem, a more rapid formation of functional complexes occurred underthe effect of the determinant complex. CONCLUSIONS: These findings demonstrate two types of functional interaction both between separate foci and between their complexes. Complete elimination of the afferent and thalamic-cortical interactions does not hinder hypersynchronization of cortical neuronal elements or formation of functional complexes and generalization of seizure activity over the cortex.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
77
Numer
Opis fizyczny
p.94-95
Twórcy
autor
  • Department of Physiology of Odessa National Medical University, Odessa, Ukraine
  • Department of Physiology of Odessa National Medical University, Odessa, Ukraine
  • Department of Botany of I.I. Mechnikov Odessa National University, Odessa, Ukraine
autor
  • Virginia Tech Carilion Research Institute, Roanoke, USA
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-b5f07a78-1274-4ffc-b498-1aa38f22e448
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.