Dietary effects of n-6:n-3 polyunsaturated fatty acid ratios on antioxidant status of the liver in goslings

• Autorzy: Wang M.Z. , Ding L. Y. , Wang J. F. , Yu L. H. , Wang H. R.
• Języki publikacji: EN

Abstrakty

EN

The objective of this study was to investigate the effects of dietary n-6:n-3 polyunsaturated fatty acid (PUFA) ratios on the oxidative stress of the liver in goslings. A total of 160 healthy Yangzhou geese was randomly divided into 4 groups, and each group was fed on diets with different n-6:n-3 PUFA ratios: A (12:1), B (9:1), C (6:1), and D (3:1), respectively. The liver was separated and antioxidant functions were evaluated on days 42, 56, and 70. The results showed that the activities of total superoxide dismutase, glutathione peroxidase, and catalase decreased when the geese aged, and were highest on d 42 in each group (P<0.05). The activities of these enzymes increased as the n-6:n-3 PUFA ratios decreased and were highest in the 3:1 group at all tested ages (P<0.05). It was also observed that the levels of H2 O2, malondialdehyde (MDA), and nitric oxide (NO) in liver tissue tended to increase with age, and were relatively higher on d 70. Furthermore, the levels of H2 O2, MDA, and NO decreased as n-6:n-3 PUFA ratios decreased and were lowest at 3:1 and 6:1 at all studied ages (P<0.05). Overall, diets containing comparatively low n-6:n-3 PUFA ratios, such as 3:1 or 6:1, could increase antioxidant function and decrease hepatocyte damage in liver tissue.

• Wydawca: -
• Czasopismo: Journal of Animal and Feed Sciences
• Rocznik: 2012
• Tom: 21
• Numer: 2
• Opis fizyczny: p.372-382,ref.

Twórcy

autor

Wang M.Z.

• College of Animal Science and Technology, Yangzhou University Yangzhou, Jiangsu province, 225009, P.R. China

autor

Ding L. Y.

• College of Animal Science and Technology, Yangzhou University Yangzhou, Jiangsu province, 225009, P.R. China

autor

Wang J. F.

• College of Animal Science and Technology, Yangzhou University Yangzhou, Jiangsu province, 225009, P.R. China

autor

Yu L. H.

• College of Animal Science and Technology, Yangzhou University Yangzhou, Jiangsu province, 225009, P.R. China

autor

Wang H. R.

• College of Animal Science and Technology, Yangzhou University Yangzhou, Jiangsu province, 225009, P.R. China

Bibliografia

• AOAC, 1990. Association of Official Analytical Chemists, Official Methods of Analysis.15th Edition. Virginia, USA
• Bertram C., Hass R., 2008. Cellular responses to reactive oxygen species-induced DNA damage and aging. Biol. Chem. 389, 211-220
• Cortinas L., Villaverde C., Galobart J., Baucells D., Codony R., Barroeta A.C., 2004. Fatty Acid content in chicken thigh and breast as affected by dietary polyunsaturation level. Poultry Sci. 83, 1155-1164
• Crane J.Q., French K.R., Buller K.M., 2005. Patterns of neuronal activation in the rat brain and spinal cord in response to increasing durations of restraint stress. Stress 8, 199-211
• Culotta E., Koshland Jr. D.E., 1992. NO news is good news. (nitric oxide; includes information about other significant advances & discoveries of 1992) (Molecule of the Year). Science 258, 1862-1864
• Desagher S., Glowinski J., Premont J., 1996. Astrocytes protect neurons from hydrogen peroxide toxicity. J. Neurosci. 16, 2553-2562
• Eder K., Flader D., Hirche F., Brandsch C., 2002. Excess dietary vitamin e lowers the activities of antioxidative enzymes in erythrocytes of rats fed salmon oil. J. Nutr. 132, 3400-3404
• Erden-Inal M., Kahraman A., Koken T., 2001. Beneficial effects of quercetin on oxidative stress induced by ultraviolet A. Clin. Exp. Dermatol. 26, 536-539
• Forsythe R.M., Xu D.Z., Lu Q., 2002. Lipopolysaccharide-induced- enterocyte-derived nitric oxide induced intestinal monolayer permeability in an autocrine fashion. Shock Augusta Ga 17, 180-184
• Johnson R.J., Kang D.H., Feig D., 2003. Is There a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 41, 1183-1186
• Lander H.M., Sehajpal P., Levine D.M., Novogrodsky A., 1993. Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds. J. Immunol. 150, 1509-1516
• Levin A.A., 1988. The reversibility of nitrobenzene-induced testicular toxicity:continuous monitoring of sperm output from vasocystotomized rats. Toxicology 53, 219-230
• Liu B.Y., Wang Z.Y., Yang H.M., Wang X.B., Hu P., Lu J., 2010. Developmental morphology of the small intestine in Yangzhou goslings. Afr. J. Biotechnol. 9, 7392-7400
• Liu L.C., 2009. Effect of unsaturated fatty acid and monensin on rumen and blood fatty acid synthesis in sheep [D] (in Chinese). Ha Erbing, Northeast Agricultural University Long J.G., Wang X.M., Gao H.X., Liu C.S., Liu Z., Miao M.Y., Liu J.K., 2005. Malonaldehyde inhibits respiratory function and enzyme activities in isolated rat liver mitochondria (in Chinese). Acad. J. Second Military Med. Univ. 26, 1131-1135
• Lu C.W., 2006. Studies on toxicology of nitrobenzene on rats [D] (in Chinese). HaErbing, Northeast Agr. Univ., pp. 23-33
• Macphail S.E., Gibney C.A., Brooks B.M., Booth C.G., Flanagan B.F., Coleman J.W., 2003. Nitric oxide regulation of human peripheral blood mononuclear cells: critical time dependence and selectivity for cytokine versus chemokine expression. J. Immunol. 171, 4809-4815
• Mayne S.T., 2003. Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidemiologic research. J. Nutr. 133, 933-940
• Muller F.L., Lustgarten M.S., Jang Y., Richardson A., Van Remmen H., 2007. Trends in oxidative aging theories. Free Radical Biol. Med. 43, 477-503
• NRC, 1994. Nutrient Requirements of Poultry. 9th revised Edition. National Academy Press. Washington, DC
• Saha K., Lajis N.H., Israf D.A., 2004. Evaluation of antioxidant and nitric oxide inhibitory of selected malaysian medicinal plants. J. Ethnopharmacol. 92, 263-267
• Shi S.R., Wang Z.Y., Yang H.M., Zhang Y.Y., 2007. Nitrogen requirement for maintence in Yangzhou goslings. Brit. Poultry Sci. 48, 205-209
• Sun G., Liu D., 2009. Effect of nitrobenzene on antioxidation of immune organ in duck (in Chinese). Chinese Poultry 31, 23-26
• Wang M., Wang D.P., Wang W.F., Hiroshi K., Han F.S., Yang X.X., He R.R., 2009. Protective effects of Baoligan capsule on liver lnjury induced by stress traditional Chinese drug (in Chinese). Res. Clin. Pharmacol. 20, 412-415
• Wang Z.Y., Shi S.R., Shi Y.J., Zhang J., Zhou Q.Y., 2008. A Comparison of methods to determine amino acid availability of feedstuffs in cecectomized ganders. Poultry Sci. 87, 96-100
• Wang Z.Y., Shi S.R., Zhou Q.Y., Yang H.M., Zou J.M., Zhang K.N., Han H.M., 2010. Response of growing goslings to dietary methionine from 28 to 70 days of age. Brit. Poultry Sci. 51, 118-121