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2011 | 71 | S |
Tytuł artykułu

Kinetic properties of leak channel currents in medial prefrontal cortex (mPFC) pyramidal neurons in rats

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The prefrontal cortex is involved in cognitive function. It has been suggested that dysfunction of mPFC occurs in widespread neuropsychiatric disorders. The purpose of this study was to classify K+ channel currents along their kinetic properties in mPFC pyramidal neurons. Channel current recordings were performed from dispersed pyramidal neurons in cell-attached configuration in symmetrical K+ solutions. The kinetic properties of 100 channel currents were analysed. A total of 27% resembled leak, TREKlike channel currents. Their mean amplitude was 6.9 pA, dwell time was 1.31 ms, and NPo was 0.009 at -50 mV. Their outward and inward conductances were 160 and 150 pS, respectively. The channel currents were strongly mechanosensitive. A total of 27% resembled TASK-like channel currents. Their mean amplitude was 2.0 pA, dwell time was 0.58 ms and NPo 0.11 at -50 mV. Inward and outward conductances were 48 and 71 pS, respectively. A total of 34% were BK-like channel currents. Their amplitude was 5.8 pA, dwell time was 1.1 ms, and NPo was 0.03 at +25 mV. Their outward conductance was 177 pS. In cell-attached configuration, the BK channel currents were only outward. The application of Ca2+ ions from the intracellular side in inside-out configuration strongly activated these channels. A total of 5% channel currents were not classified. Surprisingly, we did not find voltage dependent K+ channel currents. We concluded that the leak-type channel currents could be important players in setting the level of membrane potential in mPFC pyramidal neurons.
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-
Rocznik
Tom
71
Numer
S
Opis fizyczny
p.49
Twórcy
autor
  • Department of Physiology and Pathophysiology, Medical University of Warsaw, Warsaw, Poland
autor
  • Department of Physiology and Pathophysiology, Medical University of Warsaw, Warsaw, Poland
autor
  • Department of Physiology and Pathophysiology, Medical University of Warsaw, Warsaw, Poland
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Typ dokumentu
Bibliografia
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