Homology of DNA sequences encompassing the malignant hyperthermia mutation site in the human, porcine, and zebrine ryrl gene

• Autorzy: Gronek P , Slomski R. , Lisiecka D. , Plawski A. , Nuc K. , Banasiewicz T.
• Języki publikacji: EN

Abstrakty

EN

The RYR1 gene encoding the Ca²⁺ channel of sarcoplasmic reticulum of human skeletal muscle has been cloned and its nucleotide sequence has been determined earlier. We have used the polymerase chain reaction single strand conformation polymorphism (PCR-SSCP), and sequencing analysis for human, porcine (Sus scrofa), and zebrine (Equus grevyi) ryanodine receptor (ryrl) gene. The fragment of exon 17 of the ryr1 gene was characterized by a high homology between all the analysed species (substitution of a nucleotide is underlined): porcine ryr1 ¹⁸³⁴GTG GCC GTG CGC TCC AAC CAA GAT CT¹⁸⁵⁹ human RYR1 ¹⁸³¹GTG GCC GTG CGC TCC AAC CAA GAT CT¹⁸⁵⁶ zebrine ryr1 GTG GCC GTG CGC TCC AAC CAA GAC CT.

Słowa kluczowe

EN

homology; Equus grevyi; Sus scrofa; ryanodine receptor; chromosome; polymorphism; gene; porcine gene; man; mutation; polymerase chain reaction; DNA; malignant hyperthermia; skeletal muscle

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 1998
• Tom: 39
• Numer: 3
• Opis fizyczny: p.275-279,fig.

Twórcy

autor

Gronek P

• Agricultural University of Poznan, Wolynska 33, 60-637 Poznan, Poland

autor

Slomski R.

autor

Lisiecka D.

autor

Plawski A.

autor

Nuc K.

autor

Banasiewicz T.

Bibliografia

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