Equinatoxin II-induced lysis of the cultured endothelial cell line ECV-304

• Autorzy: Bunc M , Rozman J. , Starc R. , Macek P. , Suput D.
• Języki publikacji: EN

Abstrakty

EN

Equinatoxin II (EqT II) is a pore-forming actinoporin. Its lethality in rat tissue is due to cardio-respiratory effects. The toxin contracts the vascular smooth muscle only in the presence of intact endothelium. In our study, its effects on the endothelial cell culture ECV-304 were tested. The EqT II effects were dose-dependent and were influenced by calcium ions and sucrose. The obtained results support the conclusion that calcium ions are the intracellular messengers of the EqT II effects on the isolated endothelial cells.

Słowa kluczowe

EN

sucrose; calcium; cardiology; endothelial cell; pathophysiology; lysis; nicardipine; endothelium; rat; cardio-respiratory effect; equinatoxin II

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2002
• Tom: 07
• Numer: 2
• Opis fizyczny: p.351-353,fig.

Twórcy

autor

Bunc M

• School of Medicine, Ljubljana, Slovenia

autor

Rozman J.

autor

Starc R.

autor

Macek P.

autor

Suput D.

Bibliografia

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• 3. Lee, C., Chen, M. Y., Lue, M. H. and Ferlan, I. A. Coronary vasospasm as the primary cause of death due to equinatoxin, a toxic protein from Actinia equina. Toxicon 26 (1987) 586.
• 4. Drevenšek, G., Budihna, M. V., Šuput, D. and Bunc, M. Nicardipine dose dependently reduces the effect of equinatoxin II on coronary flow im isolated porcine heart. Eur. J. Physiol. 440 (2000) 145-146.
• 5. Belmonte, G., Pederzolli, C., Maček, P. and Menestrina, G. Pore formation by sea anemone cytolysin equinatoxin II in red blood cells and model lipid membranes. J. Membr. Biol. 131 (1993) 11-22.