Badanie wplywu dichlorfosu na metabolizm wapnia i fosforu kosci szczurow w zaleznosci od rodzaju bialka w diecie

• Autorzy: Oledzka R. , Witkowska D. , Peczlewicz E.
• Języki publikacji: PL

Abstrakty

PL

Przebadano wpływ wielokrotnego podawania DDVP w różnych dawkach i okresach czasu oraz wpływ rodzaju białka (zwierzęcego i roślinnego) na proces wymiany wapnia i fosforu z kości do płynów otaczających.

EN

The effect of dichlorphos (DDVP) on the process of mineral component exchange in bones was studied in 80-100 g rats intoxicated during 7 or 14 days with the pesticide at 0.5%, 1.0%, 5.0% and 10% DL50. Dichlorphos was administered intergastrically through a stomach tube. The rats received standard diet, synthetic diet containing 18% gluten (vegetable protein) or casein (animal protein), or protein-free diet. The experiments involved in vitro incubation of bones. The concentration of calcium was determined by the ASA method, and phosphorus level by the colorimetric method. It was demonstrated that DDVP disturbed mineral metabolism of the bones. This was reflected in the inhibition of calcium release and in the stimulation of phosphorus release from the bones to the incubation fluid. The process depended on the duration of the exposure and pesticide dose. The effect increased with increasing the duration of the exposure. It was found that bone resorption disturbances resulting from DDVP exposure were dependent on the type of the protein.

Słowa kluczowe

PL

szczury; metabolizm zwierzat; zwierzeta laboratoryjne; bialko; dichlorfos; wapn; kosci; dieta; pestycydy; fosfor

EN

rat; animal metabolism; laboratory animal; protein; dichlorvos; calcium; bone; diet; pesticide; phosphorus

• Wydawca: -
• Czasopismo: Bromatologia i Chemia Toksykologiczna
• Rocznik: 1994
• Tom: 27
• Numer: 3
• Opis fizyczny: s.237-243,tab.,wykr.,bibliogr.

Twórcy

autor

Oledzka R.

• Akademia Medyczna, Warszawa

autor

Witkowska D.

autor

Peczlewicz E.