Cereal grain resorcinolic lipids inhibit H2O2-induced peroxidation of biological membranes

• Autorzy: Kozubek A. , Nienartowicz B.
• Języki publikacji: EN

Abstrakty

EN

Cereal grain resorcinolic lipids (S-n-alk(en)ylresorcinols) at micromolar concentrations are able to protect the erythrocyte membrane against hydrogen peroxide-induced lipid oxidation. The antioxidative effect is dependent upon chain length of alkylresorcinol molecules. The C15:0 homolog (IC50 of 10 uM) exhibited strongest activity whereas for long chain homologs (C19: 0 and C23 : 0) IC50 values were higher, 32.5 and 59 uM, respectively. The protective effect of alkylresorcinolic antioxidants was also dependent on their incorporation into the membrane, that is governed by their water-membrane partition coefficient The results obtained show that alkylresorcinols should be recognized as hydrophobic, membrane-localised antioxidants.

Słowa kluczowe

EN

cereal grain; biological membrane; lipid oxidation; peroxidation; antioxidant; resorcinolic lipid

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1995
• Tom: 42
• Numer: 3
• Opis fizyczny: p.309-315,fig.

Twórcy

autor

Kozubek A.

• Wroclaw University, S.Przybyszewskiego 63-77, 51-148 Wroclaw, Poland

autor

Nienartowicz B.

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