Overexpression of human CUTA isoform2 enhances the cytotoxicity of copper to HeLa cells

• Autorzy: Yang J. , Li Q. , Yang H. , Yan L. , Yang L. , Yu L.
• Języki publikacji: EN

Abstrakty

EN

Copper, an essential transient element, can be toxic to cells when present in excess. Altered copper homeostasis is involved in pathological events of many diseases. Human CUTA isoform2 is a member of cation tolerance protein (CutA1) family. In this study, we examined the effect of CUTA isoform2 overexpression on copper toxicity. It was shown that overexpressed CUTA isoform2 sensitized HeLa cells to copper toxicity by promoting copper-induced apoptosis. The inhibition effect of excessive copper on cell proliferation was also enhanced by overexpressed CUTA isoform2. So CUTA isoform2 was implicated to be involved in the cytotoxicity of copper.

Słowa kluczowe

PL

copper toxicity; HeLa cell; cation tolerance protein; isoform; cytotoxicity; overexpression; man; apoptosis; cell proliferation

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2008
• Tom: 55
• Numer: 2
• Opis fizyczny: p.411-415,fig.,ref.

Twórcy

autor

Yang J.

• School of Life Science, Fudan University, Handan road 220, Shanghai 200433, P.R.China

autor

Li Q.

autor

Yang H.

autor

Yan L.

autor

Yang L.

autor

Yu L.

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