Calcium uptake by sarcoplasmic reticulum in the presence of the organophosphorus insecticide methylparathion

• Autorzy: Blasiak J.
• Języki publikacji: EN

Abstrakty

EN

Using an isotope labelling technique it has been shown that an organophosphorus insecticide methylparathion (0,0-diethyl 0-4-nitrophenyl phosphorothioate) depressed calcium uptake by sarcoplasmic reticulum isolated from rabbit hind leg muscle. The effect was significant for insecticide concentrations of 50 and 100 µM and was dose-dependent The insecticide exerted a more pronounced effect on calcium uptake in the presence of ATP in the reticulum environment than in the absence of ATP. The inhibitory action of methylparathion on Ca2+ accumulation by sarcoplasmic reticulum can cause a rise in myoplasmic free Ca2+, the essential prerequisite for contracture activation. Because methylparathion, as well as other organophosphorus insecticides, is primarily neurotoxic, evidence of non-specific effect could be important for assessing its environmental safety.

Słowa kluczowe

EN

calcium transport; sarcoplasmic reticulum; calcium; muscle; leg; membrane; methylparathion; organophosphorus insecticide; rabbit

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 1995
• Tom: 04
• Numer: 1
• Opis fizyczny: p.27-30,fig.

Twórcy

autor

Blasiak J.

• University of Lodz, ul.Banacha 12-16, 90-237 Lodz, Poland

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