Cytogenic mapping of DGAT1, PPARA, ADIPOR1 and CREB genes in the pig

• Autorzy: Szczerbal I , Lin L. , Stachowiak M. , Chmurzynska A. , Mackowski M. , Winter A. , Flisikowski K. , Fries R. , Switonski M.
• Języki publikacji: EN

Abstrakty

EN

In the present study we show FISH localization of 4 porcine BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (SSC4p15), PPARA (SSC5pl5), ADIPOR1 (SSC10p13) and CREB (SSC15q24). Until now the CREB and ADIPOR1 genes are considered to be monomorphic, DGAT1 is highly polymorphic, while for the PPARA gene only 1 SNP was identified. Assignment of the studied genes in relation to QTL chromosome regions for meat quality in pig chromosomes SSC4, SSC5, SSC10 and SSC15 is discussed.

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 2007
• Tom: 48
• Numer: 1
• Opis fizyczny: p.73-76,fig.,ref.

Twórcy

autor

Szczerbal I

• August Cieszkowski University of Poznan, Wolynska 33, 60-637 Poznan, Poland

autor

Lin L.

autor

Stachowiak M.

autor

Chmurzynska A.

autor

Mackowski M.

autor

Winter A.

autor

Flisikowski K.

autor

Fries R.

autor

Switonski M.

Bibliografia

• Dai MH, Xia T, Zhang GD, Chen XD, Gan L, Feng SQ, et al. 2006. Cloning, expression and chromosome localization of porcine adiponectin and adiponectin receptors genes. Domest Anim Endocrinol 30: 117-125.
• Goureau A, Yerle M, Schmitz A, Riquet J, Milan D, Pinton P, et al. 1996. Human and porcine correspondence of chromosome segments using bidirectional chromosome painting. Genomics 36: 252-262.
• Gustavsson I, 1988. Standard karyotype of the domestic pig. Committee for the Standardized Karyotype of the Domestic Pig. Hereditas 109: 151-157.
• Kim KS, Thomsen H, Bastiaansen J, Nguyen NT, Dekkers JC, Plastow GS, Rothschild MF, 2004. Investigation of obesity candidate genes on porcine fat deposition quantitative trait loci regions. Obes Res 12: 1981-1994.
• Mercade A, Sanchez A, Folch JM, 2005. Exclusion of the acyl CoA:diacylglycerol acyltransferase 1 gene (DGAT1) as a candidate for a fatty acid composition QTL on porcine chromosome 4. J Anim Breed Genet 122: 161-164.
• Nonneman D, Rohrer GA, 2002. Linkage mapping of porcine DG AT1 to a region of chromosome 4 that contains QTL for growth and fatness. Anim Genet 33: 472-473.
• Perusse L, Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, et al. 2005. The human obesity gene map: the 2004 update. Obes Res 13: 381-490.
• Pita RH, Ramos AM, Lopes PS, Guimaraes SE, Rothschild MF, 2003. Mapping of the porcine peroxisome proliferator activated receptor alpha gene to chromosome 5. Anim Genet 34: 469-470.
• Roehe R, Piastow GS, Knap PW, 2003. Quantitative and molecular genetic determination of protein and fat deposition. Homo 54: 119-131.
• Schook L, Beattie C, Beever J, Donovan S, Jamison R, Zuckermann F, et al. 2005. Swine in biomedical research: creating the building blocks of animal models. Anim Biotechnol 16: 183-190.
• Switonski M, Chmurzynska A, Mackowski M, 2003. Searching for genes controlling fatness traits in pigs - a review. Anim Sci Pap Rep 21: 73-86.