Association of chosen microsatellite markers on chromosomes 10, 11p and 14q with IDDM susceptibility in the population of midwestern Poland

• Autorzy: Jungerman M , Fichna P
• Języki publikacji: EN

Abstrakty

EN

In search for new markers of insulin-dependent diabetes (IDDM) susceptibility we studied the CATT tetranucleotide repeat in intron 1 of tyrosine hydroxylase (TH) gene on chromosome lip, the CA repeat at T-cell receptor a chain (TCRA) locus on chromosome 14q and two CA repeats at D10S211 and D10S213 loci in the chromosome 10 region containing glutamic acid decarboxylase (GAD2) gene. Alleles at these microsatellite loci were identified in a population of diabetic children and unrelated healthy controls originating from Wielkopolska, a midwestern region of Poland. We found significant association of certain alleles at TH, TCRA and D10S211 loci with diabetes in the population under study. On the contrary, none of the alleles at D10S213 locus was associated with the disease. Our findings indicate that typing of microsatellite markers may represent useful additional tool for identifying individuals at high risk of developing IDDM. Regarding loci on chromosome 10 our data and data published by other authors may suggest the extistence of two separate regions of association with IDDM susceptibility on this chromosome.

Słowa kluczowe

EN

microsatellite marker; human disease; chromosome; statistical analysis; Poland; susceptibility; insulin-dependent diabetes mellitus; health control; polymerase chain reaction; Wielkopolska region; diabetic child; population

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 1996
• Tom: 37
• Numer: 2
• Opis fizyczny: p.217-228

Twórcy

autor

Jungerman M

• Institute of Human Genetics, Polish Academy of Sciences, ul.Strzeszynska 32, 60-479 Poznan, Poland

autor

Fichna P

• Institute of Pediatrics, Medical Academy, Poznań

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