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2007 | 51 | 3 |

Tytuł artykułu

Effect of dexamethasone on the treatment of lung oedema induced by oleic acid in dogs

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The therapeutic effect of 1 mg/kg of dexamethasone on lung oedema and respiratory distress induced by 0.08 mg/kg of oleic acid (OA) in dogs was investigated into 8 dogs. One hour after OA injection, blood pH, HCO₃, pO₂, O₂Hb, and heart rate decreased, whereas COHb, pCO₂, temperature, and respiration rate increased. Lung oedema was confirmed histopathologically in a dog from the control group who died. Blood pH, COHb, temperature, and respiration rate returned to normal values after administration of dexamethasone. It has been determined that respiratory distress and lung oedema cause important changes in blood gases and the administration of a single dose of 1 mg/kg of dexamethasone is effective in the treatment of lung oedema and respiratory distress induced in dogs by OA.

Wydawca

-

Rocznik

Tom

51

Numer

3

Opis fizyczny

p.413-419,fig.,ref.

Twórcy

autor
  • Ankara University, 06110, Ankara, Turkey
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Bibliografia

  • 1. Ashbaugh D.G., Petty T.L.: The use of corticosteroids in the treatment of respiratory failure associated with massive fat embolism. Surg Gynec Obstet 1966, 123, 493-497.
  • 2. Bradley B.E., Vracko R., Sullivan K.N., Fry L.R., Akeson, W.H.: Corticosteroids as treatment for chemical pneumonitis induced by intravenous oleic acid. Clinic Orthoped Related Res 1972, 86, 230-236.
  • 3. Gross D.R.: General concepts of fluid therapy. In: Veterinary Pharmacology and Therapeutics, (Eds): N.H. Booths, L.E. McDonald, 6th ed., Iowa State University Press 1991, pp. 544-560.
  • 4. Lange N.R.: The acute respiratory distress syndrome. Am J Resp Crit Care Med 2000, 162, 271-277.
  • 5. Luce J.M.: Acute lung injury and the acute respiratory distress syndrome. Crit Care Med 1998, 26, 369-376.
  • 6. Matejovic M., Novak I., Sramek V., Rokyta R., Hora P., Nalos M.: Acute respiratory distress syndrome. Cas Lek Cesk 1999, 138, 262-267.
  • 7. Molloy W.D., Lee K.Y., Girling L., Prewitt R.M.: Treatment of canine permeability pulmonary edema: short-term effects of dobutamine, furosemide, and hydralazine. Circulation 1985, 72, 1365 -1371.
  • 8. Pellett A.A., Lord K.C., Champagne M.S., Boisblanc B.P., Johnson R.W., Levitzky M.G.: Pulmonary capillary pressure during acute lung injury in dogs. Crit Care Med 2002, 30, 403-410.
  • 9. Scillia P., Kafí S.A., Melot C., Keyzer C., Naeije R., Gevenois P.A.: Oleic acid-induced lung injury: thin- section CT evaluation in dogs. Radiology 2001, 219, 724-731.
  • 10. Su X., Bai C., Hong Q., Zhu D., He L., Wu J., Ding F., Xiaohui F., Matthay M.A: Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury. Intens Care Med 2003, 29, 2034-2042.
  • 11. Suga K., Ogasaware N., Matsunaga N., Sasai K.: Perfusion characteristics of oleic acid-injured canine lung on Gd-DTPA-enhanced dynamic magnetic resonance imaging. Invest Radiol 2001, 36, 386-400.
  • 12. Ware L.B., Matthay M.A.: The acute respiratory distress syndrome. N Engl J Med 2000, 342, 1334-1349.
  • 13. Wilson T.A., Anafi R.C., Hubmary R.D.: Mechanics of edematous lungs. J Appl Physiol 2001, 90, 2088-2093.
  • 14. Woensel J.B.M., Aalderen W.M.C., Weerd W., Jansen N.J.G., Gestel J.P.J., Markhorst D.G., Vught A.J., Bos A.P., Kimpen J.L.L: Dexamethasone for treatment of patients mechanically ventilated for lower respiratory tract infection caused by respiratory syncytial virus. Thorax 2003, 58, 383-387.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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