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2008 | 52 | 2 |

Tytuł artykułu

Tumour necrosis factor-alpha and interleukin-6 concentration in the serum of sows with the MMA syndrome

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The investigations were carried out in 10 sows that developed post-partum MMA syndrome (experimental group) and in 10 healthy sows (control) from one closed production cycle farm. The levels of TNFα and IL-6 were measured 12-24 and 48-72 h before, as well as 12-24 and 48-72 h after parturition using the ELISA. The findings revealed significantly increased postpartum levels of TNFα in both groups. Compared to the control group, the levels of TNFα in the experimental group were significantly higher 12-24 h before and 48-72 h after the parturition. The IL-6 levels significantly increased in the experimental group 48-72 h after the parturition. At both postpartum measurement points, the levels of IL-6 were significantly higher in the experimental group than those in controls. The results indicate that TNFα and IL-6 are involved in the pathogenesis of the MMA syndrome and that their determinations are useful for early diagnosis and monitoring of the disease.

Wydawca

-

Rocznik

Tom

52

Numer

2

Opis fizyczny

p.267-270,ref.

Twórcy

autor
  • University of Life Sciences in Lublin, 20-612 Lublin, Poland

Bibliografia

  • 1. Alluwaimi A.M.: The cytokines of bovine mammary gland: prospects for diagnosis and therapy. Res Vet Sci 2004, 77, 211-222.
  • 2. Bannerman D.D., Paape M.J., Lee J.W., Zhao X., Hope J.C., Rainard P.: Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection. Clin Diagn Lab Immunol 2004, 11, 463-472.
  • 3. Bowen J.M., Chamley L., Keelan J.A., Mitchell M.D.: Cytokines of the placenta and extra-placental membranes: roles and regulation during human pregnancy and parturition. Placenta 2002, 23, 257-273.
  • 4. Fossum C., Wattrang E., Fuxler L., Jensen K.T., Wallgren P.: Evaluation of various cytokines IL-6, IFN- alfa, IFN-gamma, TNF-alfa as markers for acute bacterial infection in swine - a possible role for serum interleukin- 6. Vet Immunol Immunopathol 1998, 64, 161-172.
  • 5. Hebisch G., Neumaier-Wagner P.M., Huch R., van Mandach U.: Maternal serum interleukin-1 beta, -6, and - 8 levels and potential determinants in pregnancy and peripartum. J Perinat Med 2004, 32, 475-480.
  • 6. Kushner I.: Semantics, inflammation, cytokines and commonsense. Cytokine Growth Factor Res 1998, 9, 191-196.
  • 7. Magnusson U., Pedersen-Morner A., Persson A., Karlstam E., Stemberg S., Kindahl H.: Sows intramammarily inoculated with Escherichia coli: influence of time of infection, hormone concentrations and leucocyte numbers on development of disease. J Vet Med B 2001, 37, 459-467.
  • 8. Nakajima Y., Mikami O., Yoshioka M., Motoi Y., Ito T., Ishikawa Y., Fuse M., Nakano K., Yasukawa K.: Elevated levels of tumor necrosis factor-alfa (TNF-alfa) and interleukin-6 (IL-6) activities in the sera and milk of cows with naturally occurring coliform mastitis. Res Vet Sci 1997, 62, 297-298.
  • 9. Persson A., Pedersen Morner A.E., Goransson L., Kuhl W.: A long-term study on the health status and performance of sows on different feed allowances during late pregnancy. I. Clinical observations, with special reference to agalactia postpartum. Acta Vet Scand 1989, 30, 9-17.
  • 10. Persson A., Pedersen Morner A.E., Goransson L., Kuhl W.: A long-term study on the health status and performance of sows on different feed allowances during late pregnancy. III. Escherichia coli and other bacteria, total cell content, polymorphonuclear leukocytes and pH in colostrum and milk during the first three weeks of lactation. Acta Vet Scand 1996, 37, 293-313.
  • 11. Riollet C., Rainard P., Poutrel B.: Differential induction of complement fragment C5a and inflammatory cytokines during intramammary infections with Escherichia coli and Staphylococcus aureus. Clin Diagn Lab Immunol 2000, 7, 161-167.
  • 12. Sordillo L. M., Pighetti G. M., Davis M. R.: Enhanced production of bovine tumor necrosis factor-α during the periparturient period. Vet Immunol Immunopathol 1995, 49, 263-270.
  • 13. Szczubiał M., Wawron W.: Bacterial microflora of the reproductive tracts of pigs with MMA syndrome and its antibiotic sensitivity. Medycyna Wet 2003, 59, 165-167.
  • 14. Tarasiuk K., Pejsak Z.: The role of Escherichia coli endotoxin in aetiology of post-partum agalactia in sows. Medycyna Wet 1986, 32, 323-327.
  • 15. Tracey K. J., Fong Y., Hesse D., Manogue A., Lee A., Kuo G., Lowry S., Cerami A.: Anti-cachectin / tumor necrosis factor monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 1987, 330, 662- 667.
  • 16. Wang J.F., Wang M., Ma L.G., Jiao L.G., Zhou X.Y., Lindberg J.E.: The influence of intramammary lipopolysaccharide infusion on serum Ca, P, vitamin D, cytokines and Cortisol concentrations in lactating sows. J Vet Med A 2006, 53, 113-118.
  • 17. Webel D.M., Finck B.N., Baker D.H., Johnson R.W.: Time course of increased plasma cytokine, cortisol and urea nitrogen in pigs following intraperitoneal injection of lipopolysaccharide. J Anim Sci 1997, 75, 1514-1520.
  • 18. Zhu Y.: Early inflammatory response in periparturient sows to experimentally induced Escherichia coli mastitis. Doctoral thesis, Swedish University of Agricultural Sciences, Uppsala, 2007.
  • 19. Zhu Y., Berg M., Fossum C., Magnusson U.: Proinflammatory cytokine mRNA expression in mammary tissue of sows following intramammary inoculation with Escherichia coli. Vet Immunol Immunopathol 2007, 116, 98-103.
  • 20. Zhu Y., Osterlundh I., Hulten F., Magnusson U.: Tumor necrosis factor-alfa, interleukin-6, serum amyloid A., haptoglobin and cortisol concentrations in sows following intramammary inoculation of Escherichia coli. Am J Vet Res 2004, 65, 1434-1439.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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