Aktywne metabolity fitoestrogenow stymuluja wydzielanie mediatorow luteolizy w roznych typach komorek cialka zoltego krowy

• Autorzy: Korzekwa A , Rogozinska A. , Woclawek-Potocka I. , Skarzynski D.J.

Warianty tytułu

EN

Active phytoestrogen metabolites stimulate luteolysis mediators secretion in different types of bovine corpus luteum cells

• Języki publikacji: PL

Abstrakty

EN

It has been demonstrated recently that phytoestrogens (ekwol, para-ethyl-phenol and 17β-estradiol) modulate steroidogenesis and enhance luteolytic PGF₂α and cytokine action in bovine corpus luteum (CL). The regression of bovine CL is dependent on the appropriate contact between all the types of CL cells and induction of consecutive luteolysis mediators. The aim of this study was to determine the influence of phytoestrogens on the secretion of luteolytic mediators depending on cell type and cell-to-cell contact. The studies were conducted according to the earlier established cell coculture model, which allowed the studies of interactions between steroidogenic cells, endothelial cells and immune CL in vitro. As indicators of phytoestrogene actions during luteolysis the authors measured the levels of PGF₂α, leukotrien C₄ and stable nitric oxide metabolites (NO₂/NO₃) using immuno-enzymatical assays (EIA). Phytoestrogenes stimulated secretion of PGF₂α, LTC₄ and NO₂/NO₃ in steroidogenic cells (p < 0.05) at the highest level. Cell cultures in cocultures (in composition steroidogenic, endothelial, immune cells) did not influence the effect of phytoestrogens, which indicated that steroidogenic cells are the main target for phytoestrogen action within the bovine CL.

Słowa kluczowe

PL

prostaglandyna F2 alfa; bydlo; fitoestrogeny; luteoliza; krowy; metabolity; cialko zolte

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2008
• Tom: 64
• Numer: 04B
• Opis fizyczny: s.575-578,bibliogr.

Twórcy

autor

Korzekwa A

• Instytut Rozrodu Zwierzat i Badan Zywnosci PAN, ul.Tuwima 10, 10-747 Olsztyn

autor

Rogozinska A.

autor

Woclawek-Potocka I.

autor

Skarzynski D.J.

Bibliografia

• 1.Acosta T. J., Yoshioka S., Komiyama J., Lee S. H., Grazul-Bilska A. T., Skarzynski D. J., Okuda K.: Effects of storage and passage of luteal endothelial cells on ET-1 and PGF₂α production. J. Reprod. Dev. 2007, 53, 473-480.
• 2.Bah M. M., Acosta T. J., Pilawski W., Deptula K., Okuda K., Skarzynski D. J.: Role of intraluteal prostaglandin F2a, progesterone and oxytocin in basal and pulsatile progesterone release from developing bovine corpus luteum. Prostaglandins Other Lipid. Med. 2006, 79, 218-229.
• 3.Del Vecchio R. P., Thibodeaux J. K., Hansel W.: Contact-associated interactions between large and small bovine luteal cells during the estrous cycle. Dom. Anim. Endocrinol. 1995, 12, 25-33.
• 4.Dusza L., Ciereszko R., Skarzynski D. J., Nogowski L., Opalka M., Kaminska B., Nynca A., Kraszewska O., Slomczynska M., Woclawek-Potocka I., Korzekwa A., Pruszynska-Oszmalek E., Szkudelska K.: Mechanism of phytoestrogens action in reproductive processes of mammals and birds. Reprod. Biol. 2006, 6, 151-174.
• 5.Girsh E., Milvae R. A., Wang W., Meidan R.: Effect of endothelin-1 on bovine luteal cell function: role in prostaglandin F2a-induced antisteroidogenic action. Endocrinology 1996, 137, 1306-1312.
• 6.Grazul-Bilska A. T., Reynolds L. P., Redmer D. A.: Gap junctions in the ovaries. Biol. Reprod. 1997, 57, 947-957.
• 7.Gregoraszczuk E. L.: The advantage of the aggregate culture of isolated ovarian cell types over the monolayer culture. Cytotechnology 1990, 4, 195-200.
• 8.Jaroszewski J. J., Skarzynski D. J., Blair R. M., Hansel W.: Influence of nitric oxide on the secretory function of the bovine corpus luteum: dependence on cell composition and cell-to-cell communication. Exp. Biol. Med. 2003, 228, 741-748.
• 9.Jaroszewski J. J., Skarzynski D. J., Hansel W.: Is nitric oxide a local mediator of prostaglandin F₂α-induced regression of the bovine corpus luteum? Exp. Biol. Med. 2003, 228, 1057-1062.
• 10.Korzekwa A., Woclawek-Potocka I., Rogozińska A. M., Skarżyński D. J.: Equol and para-ethyl-phenol modulate cytokines action on bovine corpus luteum. Joint Polish-Japanese Seminar: Cutting age of reproductive physiology: regulation of ovarian function. Krakow, Poland 21-24 September 2005.
• 11.Korzekwa A. J., Jaroszewski J. J., Woclawek-Potocka I., Bah M. M., Skarzynski D. J.: Luteolytic effect of prostaglandin F₂α on bovine corpus luteum depends on cell composition and contact. Reprod. Dom. Animal. 2007, oddane do druku.
• 12.Lei Z. M., Chegini N., Rao Ch. V.: Quantitative cell composition of human and bovine corpora lutea from various reproductive states. Biol. Reprod. 1991, 44, 1148-1156.
• 13.Meidan R., Milvae R. A., Weiss S., Levy N., Friedman A.: Intraovarian regulation of luteolysis. J. Reprod. Fertil. 1999, 54 (Suppl), 217-228.
• 14.Niswender G. D., Juengel J. L., Silwa P. J., Rollyson M. K., McIntush E. W.: Mechanisms controlling the function and life span of the corpus luteum. Physiol. Rev. 2000, 80, 1-29.
• 15.Nowicka E., Szkudelski R., Nogowski L.: Działanie fitoestrogenów na organizm człowieka i zwierząt. Medycyna Wet. 2006, 62, 736-738.
• 16.Pate J. L.: Intercellular communication in the bovine corpus luteum. Theriogenology 1996, 45, 1381-1397.
• 17.Pate J. L.: Involvement of immune cells in regulation of ovarian function. J. Reprod. Fertil. 1995, 49, 365-377.
• 18.Piotrowska K. K., Woclawek-Potocka I., Bah M. M., Piskula M. K., Pilawski W., Bober A., Skarzynski D. J.: Phytoestrogens and their metabolites inhibit the sensitivity of the bovine corpus luteum to luteotropic factors. J. Reprod. Dev. 2006, 52, 33-41.
• 19.Redmer D. A., Grazul-Bilska A. T., Reynolds L. P.: Contact-dependent intercellular communication of bovine luteal cells in culture. Endocrinology 1991, 129, 2757-2766.
• 20.Sakumoto R., Berisha B., Kawate N., Schams D., Okuda K.: Tumor necrosis factor-a and its receptors in bovine corpus luteum throughout the estrous cycle. Biol. Reprod. 2000, 62, 192-199.
• 21.Skarzynski D. J., Bah M. M., Wocławek-Potocka I., Deptuła K., Korzekwa A., Shibaya M., Pilawski W., Okuda K.: Roles of tumor necrosis factor-a in the regulation of the estrous cycle in cattle: an in vivo study. Biol. Reprod. 2003, 69, 1907-1913.
• 22.Skarzynski D. J., Jaroszewski J. J., Bah M. M., Deptuła K. M., Barszczewska B., Gawronska B., Hansel W.: Administration of a nitric oxide synthase inhibitor counteracts prostaglandin F₂α-induced luteolysis in cattle. Biol. Reprod. 2003, 68, 1674-1681.
• 23.Skarzynski D. J., Jaroszewski J. J., Okuda K.: Role of tumor necrosis factor-a and nitric oxide in luteolysis in cattle. Dom. Animal Endocrinol. 2005, 29, 340-346.
• 24.Townson T. H., O’Connor C. L., Pru J. K.: Expression of Monocyte Chemoattractant Protein-1 and distribution of immune cell populations in the bovine Corpus Luteum throughout the estrous cycle. Biol. Reprod. 2002, 66, 361-366.
• 25.Woclawek-Potocka I., Acosta T. J., Korzekwa A., Bah M. M., Shibaya M., Okuda K., Skarzynski D. J.: Phytoestrogens modulate prostaglandin production in bovine endometrium: cell type specificity and intracellular mechanisms. Exp. Biol. Med. 2005, 230, 326-333.
• 26.Woclawek-Potocka I., Bober A., Korzekwa A., Okuda K., Skarzynski D. J.: Equol and para-ethyl-phenol stimulate prostaglandin F2a secretion in bovine corpus luteum: intracellular mechanisms of action. Prostaglandins Other Lipid. Mediat. 2006, 79, 287-297.
• 27.Woclawek-Potocka I., Borkowski K., Korzekwa A., Okuda K., Skarzynski D. J.: Phyto- and endogenous estrogens differently activate intracellular calcium ions in the bovine endometrial cells. J. Reprod. Dev. 2006, 52, 731-740.