Antinociceptive and anti-inflammatory activities of Trigonella foenum-greacum seeds

• Autorzy: Laroubi A , Farouk L. , Aboufatima R. , Bensalah A. , Zyad A. , Benharref A. , Bagri A. , Chait A.

Warianty tytułu

PL

Przeciwbolowe i przeciwzapalne dzialanie nasion Trigonella foenum-greacum

• Języki publikacji: EN

Abstrakty

EN

Trigonella foenum-graecum L.(Leguminosae), known in Morocco as “Helba”, is used in folk medicine for its anti-ulcer, anti-inflammatory, cicatrizing activities and to treat various pain-related physiological states. In present study, we attempted to verify the possible antinociceptive and anti-inflammatory activities of different extracts obtained from the seeds of this plant. Three experimental models were used (i.e. acetic acid, formalin, and hot-plate tests) in order to characterize both the analgesic and the anti inflammatory effects. Dichloromethane (350 and 500 mg/kg), ethyl acetate [(EAE) (350 and 500 mg/kg)], aqueous (500 mg/kg) and butanolic (500 mg/kg) extracts significantly and in a dose-dependent manner reduced the pain induced by IP injection of acetic acid. In the formalin test, the extracts, except EAE, significantly reduced the painful stimulus but only in the early phase of the test. On the contrary, these extracts, except EAE, were ineffective in increasing the latency of licking or jumping in the hot-plate test. These results suggest that the compounds present in the extracts activated both central and peripheral mechanisms to elicit the analgesic and anti-inflammatory effects. However, pharmacological and chemical studies are continued in order to characterize these mechanisms and also to identify the active principles present in each extract.

PL

Trigonella foenum-graecum L.(Leguminosae) znana w Maroku pod nazwą Helba, jest używana w medycynie tradycyjnej jako środek przeciwwrzodowy, przeciwzapalny, wspomagający gojenie ran i w leczeniu wielu stanów związanych z odczuwaniem bólu. W niniejszej pracy podjęto próbę sprawdzenia możliwego działania przeciwbólowego i przeciwzapalnego różnych wyciągów z nasion tej rośliny. Zastosowano trzy modele eksperymentalne (tj. test z użyciem kwasu octowego, formaliny i hot-plate) w celu określenia działania zarówno przeciwbólowego, jak i przeciwzapalnego. Ekstrakty sporządzone za pomocą dichlorometanu (350 i 500 mg/kg), octanu etylu [(EAE) (350 i 500 mg/kg)], wody (500 mg/kg) i butanolu (500 mg/kg) wyraźnie i dawkozależnie zmniejszały odczuwanie bólu spowodowanego przez dootrzewnowe podanie kwasu octowego. W teście formalinowym, za wyjątkiem EAE, badane ekstrakty wyraźnie redukowały odczuwanie bodźca bólowego, ale tylko we wczesnej fazie działania danego testu. Natomiast ekstrakty, z wyjątkiem EAE, nie były efektywne w zmianie parametrów charakteryzujących test hot-plate (opóźnienie lizania czy czasu letencji skoku). Na podstawie otrzymanych wyników można sugerować, że związki obecne w wyciągach działały przeciwbólowo i przeciwzapalnie zarówno poprzez mechanizmy centralne, jak i obwodowe. Trwają dalsze prace, zarówno farmakologiczne, jak i chemiczne w celu określenie dokładnych mechanizmów, jak i zidentyfikowania aktywnych związków w każdym z badanych wyciągów.

Słowa kluczowe

EN

Morocco; traditional medicine; folk medicine; medicinal plant; herbal plant; fenugreek; Trigonella foenum-graecum; seed; medicinal property; analgesic activity; antiinflammatory activity; plant extract; seed extract; acetic acid; plant test; animal test; formalin test; hot plate test; writhing test; nociception; pharmacological research

• Wydawca: -
• Czasopismo: Herba Polonica
• Rocznik: 2009
• Tom: 55
• Numer: 4
• Opis fizyczny: p.105-118,fig.,ref.

Twórcy

autor

Laroubi A

• Cadi-Ayyad University, Semlalia Marrakech, Morocco

autor

Farouk L.

autor

Aboufatima R.

autor

Bensalah A.

autor

Zyad A.

autor

Benharref A.

autor

Bagri A.

autor

Chait A.

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