Synaptic protein UNC-13 interacts with an F-box protein that may target it for degradation by proteasomes

• Autorzy: Polinsky C. , Houston C. , Vado J. , Shaikh A. , Kohn R.E.
• Języki publikacji: EN

Abstrakty

EN

UNC-13 protein participates in regulating neurotransmitter release. In Drosophila melanogaster, proteasomal degradation controls UNC-13 levels at synapses. Function of the amino-terminal region of a 207 kDa form of Caenorhabditis elegans UNC-13 is unknown. Yeast two-hybrid and secondary yeast assays identified an F-box protein that interacts with this amino-terminal region. As F-box proteins bind proteins targeted for proteasomal degradation, this protein may participate in degrading a subset of UNC-13 proteins, suggesting that different forms of UNC-13 are regulated differently. Yeast assays also identified an exonuclease, a predicted splicing factor, and a protein with coiled-coil domains, indicating that UNC-13 may affect RNA function.

Słowa kluczowe

EN

F-box protein; yeast two-hybrid; Drosophila melanogaster; Caenorhabditis elegans; synaptic neurotransmission; degradation; UNC-13 protein; protein; proteasome; RNA function

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2006
• Tom: 53
• Numer: 1
• Opis fizyczny: p.145-148,fig.,ref.

Twórcy

autor

Polinsky C.

• Ursinus College, Collegeville, PA, USA

autor

Houston C.

autor

Vado J.

autor

Shaikh A.

autor

Kohn R.E.

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