Aminergic control of vasopressin secretion in the conscious rat

• Autorzy: Wells T , Forsling M.L.
• Języki publikacji: EN

Abstrakty

EN

The influence of aminergic pathways on basal and stimulated vasopressin (AVP) release was studied in conscious rats, the stimulus for hormone release being an intracerebroventricular (ICV) injection of 5 µl 0.85M sodium chloride. The animals were treated with either phenoxybenzamine, propranolol or haloperidol prior to administration of the central hypertonic stimulus. Phenoxybenzamine elevated basal plasma vasopressin concentrations, while propranolol and haloperidol had no effect. The secretion of АVР in response to the hypertonic stimulus was potentiated by phenoxybenzamine and haloperidol, but the effect of propranolol was equivocal. The antagonists had no effect on basal arterial pressure at the time of hypertonic saline administration or the pressor response to ICV sodium chloride.

Słowa kluczowe

EN

vasopressin; dopamine; noradrenaline; osmoreceptor; secretion; rat

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1992
• Tom: 43
• Numer: 1
• Opis fizyczny: p.59-64,fig.

Twórcy

autor

Wells T

• Department of Obstetrics and Gynaecology, UMDS., St. Thomas'Campus, Lambeth Palace Road; London, SE1 7EH. U.K.

autor

Forsling M.L.

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